NDLI: Clinical characteristics and survival outcomes of super-elderly hepatocellular carcinoma patients not indicated for surgical resection.

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Clinical characteristics and survival outcomes of super-elderly hepatocellular carcinoma patients not indicated for surgical resection.

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Clinical characteristics and survival outcomes of super-elderly hepatocellular carcinoma patients not indicated for surgical resection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kinoshita, Akiyoshi Onoda, Hiroshi Ueda, Kaoru Imai, Nami Iwaku, Akira Tanaka, Ken Fushiya, Nao Koike, Kazuhiko Nishino, Hirokazu Tajiri, Hisao
Description	Country affiliation: Japan Author Affiliation: Kinoshita A ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Onoda H ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Ueda K ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Imai N ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Iwaku A ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Tanaka K ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Fushiya N ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Koike K ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Nishino H ( Division of Gastroenterology and Hepatology, Jikei University Daisan Hospital, Tokyo, Japan.); Tajiri H ( Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.)
Abstract	AIM: Considering the dramatic increase in average life expectancy during the 20th century throughout the world, the management of elderly patients with cancer has become a global issue. We herein investigated the clinical characteristics and outcomes of super-elderly hepatocellular carcinoma (HCC) patients over 80 years old not indicated for surgical resection. METHODS: We retrospectively evaluated 206 newly diagnosed HCC patients. The patients were divided into two groups according to their age at inclusion; a super-elderly group (n = 37, ≥80 years) and a younger group (n = 169, <80 years). We compared the clinical characteristics, overall survival (OS) and disease-specific survival (DSS) rates among the two groups. Both univariate and multivariate analyses were performed to identify the factors associated with the OS and DSS. RESULTS: The proportion of women was higher in the super-elderly group than in the younger group (P = 0.017). There were no significant differences in the OS (P = 0.171) or DSS (P = 0.176) between the two groups. The multivariate analysis revealed that only the Cancer Liver Italian Program score (hazard ratio [HR], 2.972; P < 0.0001; HR, 3.694; P < 0.0001) was independently associated with the OS and DSS. Age was not found to be associated with the OS or DSS according to either the univariate or multivariate analysis. CONCLUSION: There were no significant differences in the OS and DSS rates among the super-elderly HCC patients and younger HCC patients not indicated for surgical resection. An advanced age itself does not restrict the therapeutic approach, even in super-elderly HCC patients not indicated for surgical resection.
File Format	HTM / HTML
ISSN	13866346
Issue Number	3
Journal	Hepatology Research
Volume Number	46
e-ISSN	1872034X
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2016-03-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Hepatology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Hepatology

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