NDLI: Natural language processing for the development of a clinical registry: a validation study in intraductal papillary mucinous neoplasms.

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Natural language processing for the development of a clinical registry: a validation study in intraductal papillary mucinous neoplasms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Al-Haddad, Mohammad A. Friedlin, Jeff Kesterson, Joe Waters, Joshua A. Aguilar-Saavedra, Juan R. Schmidt, C. Max
Spatial Coverage	Indiana
Description	Country affiliation: United States Author Affiliation: Al-Haddad MA ( Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.)
Abstract	BACKGROUND: Medical natural language processing (NLP) systems have been developed to identify, extract and encode information within clinical narrative text. However, the role of NLP in clinical research and patient care remains limited. Pancreatic cysts are common. Some pancreatic cysts, such as intraductal papillary mucinous neoplasms (IPMNs), have malignant potential and require extended periods of surveillance. We seek to develop a novel NLP system that could be applied in our clinical network to develop a functional registry of IPMN patients. OBJECTIVES: This study aims to validate the accuracy of our novel NLP system in the identification of surgical patients with pathologically confirmed IPMN in comparison with our pre-existing manually created surgical database (standard reference). METHODS: The Regenstrief EXtraction Tool (REX) was used to extract pancreatic cyst patient data from medical text files from Indiana University Health. The system was assessed periodically by direct sampling and review of medical records. Results were compared with the standard reference. RESULTS: Natural language processing detected 5694 unique patients with pancreas cysts, in 215 of whom surgical pathology had confirmed IPMN. The NLP software identified all but seven patients present in the surgical database and identified an additional 37 IPMN patients not previously included in the surgical database. Using the standard reference, the sensitivity of the NLP program was 97.5% (95% confidence interval [CI] 94.8-98.9%) and its positive predictive value was 95.5% (95% CI 92.3-97.5%). CONCLUSIONS: Natural language processing is a reliable and accurate method for identifying selected patient cohorts and may facilitate the identification and follow-up of patients with IPMN.
File Format	HTM / HTML
ISSN	1365182X
e-ISSN	14772574
DOI	10.1111/j.1477-2574.2010.00235.x
Journal	HPB
Issue Number	10
Volume Number	12
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Gastroenterology Carcinoma, Pancreatic Ductal Pathology Carcinoma, Papillary Data Mining Natural Language Processing Neoplasms, Cystic, Mucinous, And Serous Pancreatic Cyst Pancreatic Neoplasms Precancerous Conditions Registries Surgery Disease Progression Indiana Prognosis Reproducibility Of Results Time Factors Comparative Study Research Support, Non-u.s. Gov't Validation Studies
Content Type	Text
Resource Type	Article
Subject	Hepatology Gastroenterology

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