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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Danielson, Phillip B. Sun, Hong-Yu Melton, Terry Kristinsson, Richard |
| Description | Country affiliation: United States Author Affiliation: Danielson PB ( University of Denver, Department of Biological Sciences, 2190 E. Iliff Avenue Rm 102, Denver, CO 80208, USA. pdaniels@du.edu) |
| Abstract | Mitochondrial DNA (mtDNA) sequencing can provide crucial information to forensic investigators when the quantity and quality of DNA would otherwise be limiting. The difficulty of analyzing mtDNA mixtures, however, has been a significant obstacle to its broader use in forensics. Denaturing high-performance liquid chromatography (DHPLC) in combination with direct sequencing makes it possible to determine the linkage phase of individual amplicons in a mixture. The reliability of the approach is based, in part, on the strong correlation between a change in the relative quantities of different DNA amplicons in a given mixture versus a change in the relative electrophoretic peak heights at mixed base positions. Using standard operating procedures previously validated for use in forensic laboratories, this approach enables sequence-specific fractionation of natural (heteroplasmic) or situational (multi-contributor) DNA mixtures prior to direct sequencing. As a novel approach for the rapid and accurate analysis of DNA mixtures, DHPLC may aid criminal investigators by making it possible to obtain definitive mitochondrial DNA results from otherwise challenging samples. |
| File Format | HTM / HTML |
| ISSN | 18724973 |
| Issue Number | 2 |
| Volume Number | 1 |
| e-ISSN | 18780326 |
| Journal | Forensic Science International: Genetics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2007-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Forensic Sciences Chromatography, High Pressure Liquid Methods Dna, Mitochondrial Genetics Isolation & Purification Forensic Genetics Electrophoresis Humans Nucleic Acid Denaturation Reproducibility Of Results Sequence Analysis, Dna Journal Article Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Pathology and Forensic Medicine |
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