NDLI: Ceftiofur use in finishing swine barns and the recovery of fecal Escherichia coli or Salmonella spp. resistant to ceftriaxone.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lutz, Eric A. McCarty, Marlena J. Mollenkopf, Dixie F. Funk, Julie A. Gebreyes, Wondwossen A. Wittum, Thomas E.
Spatial Coverage	North Carolina
Description	Country affiliation: United States Author Affiliation: Lutz EA ( Division of Community, Environment, and Policy, Mel & Enid Zuckerman College of Public Health, The University of Arizona, Tucson, Arizona, USA.)
Abstract	The objective of this study was to investigate the association between ceftiofur use policy in finishing swine barns and recovery of fecal Escherichia coli or Salmonella spp. resistant to ceftriaxone. The study population included 54 finishing swine barns from three companies located in North Carolina. The barns were each classified according to their reported therapeutic ceftiofur use rates of 'Rare,' 'Moderate,' and 'Common.' Fecal samples from the barns were cultured for the presence of E. coli and Salmonella spp. resistant to ceftriaxone using selective media designed to recover rare organisms expressing the AmpC ß-lactamase phenotype. A total of 1899 swine fecal samples yielded 1193 E. coli (63%) resistant to ceftriaxone. Recovery rates by ceftiofur use classification were 45% for Rare, 73% for Moderate, and 68% Common ceftiofur use groups. Barns reporting Rare ceftiofur use had a lower odds of recovery of E. coli (OR=0.32; p<0.001) resistant to ceftriaxone compared to Common use barns. The overall Salmonella spp. prevalence was 63.8% (n=714). Of these, 65 Salmonella were resistant to ceftriaxone with the highest rate (6%) found in the Common ceftiofur use group, followed by Rare (4.1%) and Moderate (0.15%). The odds of recovery of Salmonella resistant to ceftriaxone were similar for barns with ceftiofur use classified as Rare and Common. Samples from barns with ceftiofur use classified as Moderate had a lower odds (OR=0.02; p<0.01) of recovery of Salmonella resistant to ceftriaxone than barns classified as Common. Our result is consistent with the hypothesis that the use of ceftiofur in finishing swine barns, beyond its rare application, may influence the recovery of enteric E. coli with resistance to cephalosporin drugs, although other unmeasured factors appear to be important in the recovery of cephalosporin-resistant Salmonella. The dissemination of enteric bacteria with resistance to cephalosporins has the potential to impact both veterinary and human therapeutic treatment options.
File Format	HTM / HTML
ISSN	15353141
Issue Number	11
Volume Number	8
e-ISSN	15567125
Journal	Foodborne Pathogens and Disease
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2011-11-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Microbiology Discipline Parasitology Discipline Nutritional Sciences Anti-bacterial Agents Pharmacology Ceftriaxone Cephalosporins Escherichia Coli Drug Effects Feces Microbiology Salmonella Animals Cephalosporin Resistance Cross-sectional Studies Drug Resistance, Bacterial Isolation & Purification Escherichia Coli Infections Veterinary Humans Logistic Models Microbial Sensitivity Tests North Carolina Salmonella Infections, Animal Swine Swine Diseases Journal Article Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology Microbiology Applied Microbiology and Biotechnology Food Science

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