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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rofail, Pierre Tadros, Mariam Ywakim, Riham Tadrous, Mina Krug, Allison Cosler, Leon E. |
| Spatial Coverage | United States |
| Description | Country affiliation: United States Author Affiliation: Rofail P ( Albany College of Pharmacy and Health Sciences, 106 New Scotland Ave, Albany, NY 12208, USA.) |
| Abstract | For oncology patients, febrile neutropenia (FN) can be a serious and costly toxicity of chemotherapy, often forcing a reduction in chemotherapy dose intensity and/or duration. Several therapeutic agents are used to reduce the occurrence of neutropenic episodes: granulocyte colony-stimulating factors (G-CSFs) and granulocyte-macrophage colony-stimulating factors. Appropriate administration of colony-stimulating factors reduces the risk of FN episodes and the costs associated with FN treatment. In the USA, the two most commonly used G-CSFs are filgrastim and the longer-acting pegfilgrastim. This pharmacoeconomic review of pegfilgrastim briefly considers some of the early research of G-CSFs, then focuses on the most recent comparative studies of pegfilgrastim against the backdrop of forthcoming US patent expiration for both products. The authors conclude with commentary on the market for pegfilgrastim in light of the growing debate surrounding the optimal selection of patients, treatment costs and future alternatives for the use of these agents in chemotherapy. |
| File Format | HTM / HTML |
| ISSN | 14737167 |
| Issue Number | 6 |
| Volume Number | 12 |
| e-ISSN | 17448379 |
| Journal | Expert Review of Pharmacoeconomics & Outcomes Research |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antineoplastic Agents Adverse Effects Granulocyte Colony-stimulating Factor Therapeutic Use Neutropenia Prevention & Control Administration & Dosage Dose-response Relationship, Drug Drug Costs Economics, Pharmaceutical Fever Chemically Induced Economics Filgrastim Humans Patents As Topic Patient Selection Recombinant Proteins United States Comparative Study Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Health Policy |
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