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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | de la Torre, Inmaculada Valor, Lara Nieto, Juan Carlos Hernández-Flórez, Diana Hernandez, Diana Martinez, Lina Gonzalez, Carlos M. Monteagudo, Indalecio Longo, Javier Lopez Montoro, Maria Carreño, Luis |
| Description | Country affiliation: Spain Author Affiliation: de la Torre I ( Hospital General Universitario Gregorio Marañón, Rheumatology Department, Dr Esquerdo 46, 28007, Madrid, Spain. inma.torre.ortega@googlemail.com) |
| Abstract | Rheumatoid arthritis (RA) is a chronic systemic disease that leads to increases in health system economic burden through direct and indirect costs, including chronic treatment, reduced productivity and premature mortality. Anti-TNF agents have represented a major advance in the treatment of RA. The most commonly used (adalimumab, etanercept and infliximab) have demonstrated their cost-effectiveness at label doses. However, physicians may need to adapt the treatment by increasing the dose when a drug is not effective enough or by reducing it when there is a sustained effectiveness. In a cross-sectional study conducted in our hospital in which information from RA patients treated with anti-TNF drugs under conventional and modified doses were collected, the authors analyzed the costs of the medication in order to estimate the mean patient-year cost, the annual costs related to clinical efficacy and the cost per responder patient to anti-TNF treatment when dosage modification is undertaken in daily clinical practice. |
| File Format | HTM / HTML |
| ISSN | 14737167 |
| Issue Number | 3 |
| Volume Number | 13 |
| e-ISSN | 17448379 |
| Journal | Expert Review of Pharmacoeconomics & Outcomes Research |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2013-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antirheumatic Agents Therapeutic Use Arthritis, Rheumatoid Drug Therapy Tumor Necrosis Factor-alpha Antagonists & Inhibitors Adalimumab Adult Aged Antibodies, Monoclonal Administration & Dosage Economics Antibodies, Monoclonal, Humanized Cross-sectional Studies Dose-response Relationship, Drug Drug Costs Etanercept Female Humans Immunoglobulin G Infliximab Male Middle Aged Receptors, Tumor Necrosis Factor Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Health Policy |
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