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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Genro, Júlia P. Kieling, Christian Rohde, Luis A. Hutz, Mara H. |
| Description | Country affiliation: Brazil Author Affiliation: Genro JP ( Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.) |
| Abstract | Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric condition that affects approximately 5.3% of children worldwide. This disorder is defined by a combination of symptoms of inattention and hyperactivity/impulsivity. Diagnosis is based on impairment in these two domains determining several problems in personal and academic life. Although it is known that genetic and environmental factors are important in ADHD etiology, how these factors influence the brain and consequently behavior is still under debate. There seems to be a consensus in the literature that a fronto-subcortical dysfunction is responsible, at least in part, for the ADHD spectrum. Considering that these brain regions are rich in dopamine (DA), the DA hypothesis has an important role to understand ADHD pathophysiology. The main goal of the present review is to show evidence from different areas that support the idea that dysregulation in the DA system underlies ADHD. We discuss here evidences from animal models, pharmacology, brain imaging and genetics studies. |
| File Format | HTM / HTML |
| ISSN | 14737175 |
| Issue Number | 4 |
| Volume Number | 10 |
| e-ISSN | 17448360 |
| Journal | Expert Review of Neurotherapeutics |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Discipline Neurology Attention Deficit Disorder With Hyperactivity Metabolism Physiopathology Dopamine Animals Etiology Brain Humans Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Neurology (clinical) Pharmacology (medical) |
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