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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zuardi, Antonio Waldo Guimarães, Fransisco Silveira Hallak, Jaime Eduardo C. Crippa, José Alexandre S. |
| Description | Country affiliation: Brazil Author Affiliation: Zuardi AW ( Department of Neurosciences and Behavior, Division of Psychiatry, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Hospital das Clínicas-Terceiro Andar, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, CEP - 14049-800, Brazil. awzuardi@fmrp.usp.br) |
| Abstract | Evaluation of: Dalton VS, Long LE, Weickert CS, Zavitsanou K. Paranoid schizophrenia is characterized by increased CB(1) receptor binding in the dorsolateral prefrontal cortex. Neuropsychopharmacology 36(8), 1620–1630 (2011). Increased binding of type 1 cannabinoid (CB1) receptor ligands in the dorsolateral prefrontal cortex and other areas has been shown in post-mortem studies, although there are some inconsistent results. The study by Dalton et al. employed a more rigorous control for potentially confounding variables and investigated whether the density of CB1 receptors and their mRNA expression were different in subtypes of schizophrenia patients. They observed an increased density of CB1 receptors in paranoid schizophrenia as compared with nonparanoid schizophrenia patients and controls. This finding strengthens the evidence for the involvement of endocannabinoids in schizophrenia. However, it is difficult to reconcile with previous observations of increased levels of anandamide in the cerebrospinal fluid in paranoid schizophrenia, since CB1 receptor agonists were shown to induce the downregulation of these receptors. The precise role of the endocannabinoid system in the pathophysiology of schizophrenia remains far from understood. |
| File Format | HTM / HTML |
| ISSN | 14737175 |
| Issue Number | 8 |
| Journal | Expert Review of Neurotherapeutics |
| Volume Number | 11 |
| e-ISSN | 17448360 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2011-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Discipline Neurology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Neurology (clinical) Pharmacology (medical) |
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