NDLI: Childhood leukodystrophies: a clinical perspective.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kohlschütter, Alfried Eichler, Florian
Description	Country affiliation: Germany Author Affiliation: Kohlschütter A ( Children's Hospital University Medical Center, Hamburg, Germany. kohlschuetter@uke.uni-hamburg.de)
Abstract	Leukodystrophies are white matter disorders that are genetic in nature. In the young, they represent an important cause of progressive neurological disability. They are frequently recognized on MRI, but their identification remains a challenge. Their diagnosis is important for prognostication, palliative and experimental treatment, as well as family screening. The diagnostic strategy rests upon clinical clues and MRI patterns, complemented by appropriately selected electrophysiological and laboratory testing. Considerable overlap exists between white and gray matter disease, as neuronal degeneration will result in myelin loss. An understanding of the pathophysiology and natural disease evolution is necessary to understand the risks and benefits of experimental and palliative treatments.
File Format	HTM / HTML
ISSN	14737175
Issue Number	10
Volume Number	11
e-ISSN	17448360
Journal	Expert Review of Neurotherapeutics
Language	English
Publisher	Taylor & Francis
Publisher Date	2011-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Therapeutics Discipline Neurology Leukodystrophy, Globoid Cell Diagnosis Leukodystrophy, Metachromatic Nerve Fibers, Myelinated Pathology Neurodegenerative Diseases Child Humans Infant Infant, Newborn Physiopathology Therapy Magnetic Resonance Imaging Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Neuroscience Neurology (clinical) Pharmacology (medical)

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