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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Forde, Patrick M. Ettinger, David S. |
| Description | Country affiliation: United States Author Affiliation: Forde PM ( Lung Cancer Research Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.) |
| Abstract | Therapy for advanced non-small-cell lung cancer has developed significantly with new awareness of histologic subtype as an important factor in guiding treatment and the development of targeted agents for molecular subgroups harboring critical mutations that spur on cancer growth. In this comprehensive review, we look back at developments in targeted therapy for advanced non-small-cell lung cancer, reviewing in detail efforts, both successful and in some cases less so, to target EGFR, VEGF and ALK. This review provides an overview of where the field stands at present and the areas we feel are most likely to provide challenges and potential successes in the next 5 years including immune checkpoint inhibition, epigenetic therapy and driver mutation targeting. |
| File Format | HTM / HTML |
| ISSN | 14737140 |
| e-ISSN | 17448328 |
| DOI | 10.1586/era.13.47 |
| Journal | Expert Review of Anticancer Therapy |
| Issue Number | 6 |
| Volume Number | 13 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2013-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Therapeutics Discipline Oncology Carcinoma, Non-small-cell Lung Drug Therapy Lung Neoplasms Molecular Targeted Therapy Genetics Pathology Drug Resistance, Neoplasm Epigenesis, Genetic Mutation Protein Kinase Inhibitors Pharmacology Therapeutic Use Protein Transport Drug Effects Pyrazoles Pyridines Receptor Protein-tyrosine Kinases Metabolism Receptor, Epidermal Growth Factor Vascular Endothelial Growth Factor A Antagonists & Inhibitors |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
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