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Effects of risperidone on dopamine receptor subtypes in developing rat brain.
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Moran-Gates, Taylor Grady, Christopher Shik Park, Young Baldessarini, Ross J. Tarazi, Frank I. |
| Description | Country affiliation: United States Author Affiliation: Moran-Gates T ( Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA.) |
| Abstract | The atypical antipsychotic risperidone is often prescribed to pediatric patients with neuropsychiatric disorders, though its effects on the developing brain remain unclear. Accordingly, we studied the effects of repeated treatment of risperidone on dopamine receptors in brain regions of juvenile rat. Levels of dopamine receptors (D(1), D(2), D(3), D(4)) in forebrain regions of juvenile rats were quantified after 3 weeks of treatment with three different doses of risperidone (0.3, 1.0 and 3.0 mg/kg) and compared findings to those in adult rats treated with risperidone (3.0 mg/kg/day) previously. Risperidone (at 1.0 and 3.0 mg/kg/day) increased levels of D(1) receptors in nucleus accumbens and caudate-putamen of juvenile, but not adult rats. Conversely, all three doses of risperidone dose-dependently increased D(2) labeling in medial prefrontal cortex and hippocampus, and D(4) receptor in nucleus accumbens, caudate-putamen and hippocampus of juvenile animals as well as in adults. Only the high dose of risperidone (3.0 mg/kg) increased D(2) receptors in caudate-putamen in both juvenile and adult brain. D(3) receptors were not altered by risperidone in any brain region at any dose or age. The findings indicate dose-dependent effects of risperidone on dopamine receptors in developing animals, and that juvenile animals are more sensitive than adults to the cerebral effects of risperidone. |
| File Format | HTM / HTML |
| ISSN | 0924977X |
| e-ISSN | 18737862 |
| Journal | European Neuropsychopharmacology |
| Issue Number | 6-7 |
| Volume Number | 17 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2007-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Discipline Psychopharmacology Brain Physiology Receptors, Dopamine Risperidone Pharmacology Animals Drug Effects Growth & Development Caudate Nucleus Cerebral Cortex Dopamine Antagonists Hippocampus Nucleus Accumbens Putamen Rats, Sprague-dawley Classification Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Biological Psychiatry Neurology (clinical) Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
