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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Manchia, Mirko Zai, Clement C. Squassina, Alessio Vincent, John B. De Luca, Vincenzo Kennedy, James L. |
| Description | Country affiliation: Italy Author Affiliation: Manchia M ( Laboratory of Molecular Genetics, Department of Neurosciences B.B. Brodie, University of Cagliari, Cagliari, Italy. mirkomanchia@unica.it) |
| Abstract | Bipolar Disorder (BPD) is a complex psychiatric disease with a relevant underlying genetic basis. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). 5-HTTLPR polymorphism associated with early onset component under recessive and additive model. HTR2A T102C, HTR2C Cys23Ser and 5-HTTLPR interaction terms associated with early onset component under dominant, recessive and additive model. These findings suggest a role of genes codifying for elements of the serotonergic system in influencing the AAO in BPD. |
| File Format | HTM / HTML |
| ISSN | 0924977X |
| Issue Number | 9 |
| Volume Number | 20 |
| e-ISSN | 18737862 |
| Journal | European Neuropsychopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Psychopharmacology Bipolar Disorder Genetics Polymorphism, Single Nucleotide Serotonin Plasma Membrane Transport Proteins Adult Age Of Onset Epidemiology Female Genotype Humans Male Middle Aged Receptor, Serotonin, 5-ht2a Receptor, Serotonin, 5-ht2c Regression Analysis Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Biological Psychiatry Neurology (clinical) Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
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