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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nielsen, Jimmi Røge, Rasmus Schjerning, Ole Sørensen, Holger J. Taylor, David |
| Spatial Coverage | Denmark |
| Description | Country affiliation: Denmark Author Affiliation: Nielsen J ( Centre for Schizophrenia, Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark. jin@rn.dk) |
| Abstract | Despite its unsurpassed efficacy in treatment-resistant schizophrenia, clozapine remains underutilized. Trends in the prescription of clozapine in patients with ICD-10 F20.x schizophrenia were assessed using data from Danish national registers. Three substudies were carried out: (i) an assessment of differences in national prescription patterns between 1996 and 2007 using a cross-sectional design; (ii) a comparison of time from first schizophrenia diagnosis to first prescription of clozapine in a five-year cohort study, using the Cox regression model, of two patient groups who were first diagnosed in 1996 and in 2003; (iii) an assessment of differences in the general psychiatric hospitals' use of clozapine in 2009. The results are as follows: (i) The percentage of schizophrenia patients receiving clozapine rose from 9.0% in 1996 to 10.1% in 2007 (p<0.001). In the same period, the percentage of patients having clozapine treatment augmented with another antipsychotic increased from 43.1% to 64.2%, p<0.001. (ii) Time from diagnosis with schizophrenia until first clozapine prescription was longer for patients diagnosed in 2003 compared to those diagnosed in 1996 (HR: 0.28 CI: 0.16-0.49). (iii) In 2009 there was significant variation in clozapine administration from one hospital to the other, with percentages of patients receiving the drug ranging from 5.7% to 16.8%, with 10.2% as the national mean. Although, the percentage of schizophrenia patients receiving clozapine increased from 1996 to 2007, the time from diagnosis of schizophrenia until first prescription of clozapine increased. |
| File Format | HTM / HTML |
| ISSN | 0924977X |
| Issue Number | 11 |
| Volume Number | 22 |
| e-ISSN | 18737862 |
| Journal | European Neuropsychopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Psychopharmacology Antipsychotic Agents Therapeutic Use Clozapine Schizophrenia Drug Therapy Cohort Studies Cross-sectional Studies Databases, Factual Denmark Drug Prescriptions Drug Resistance Drug Therapy, Combination Female Hospitals, Psychiatric Humans International Classification Of Diseases Male Physician's Practice Patterns Proportional Hazards Models Registries Spatio-temporal Analysis Time-to-treatment Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Biological Psychiatry Neurology (clinical) Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
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