NDLI: Detection of the acute effects of hydrocortisone in the hippocampus using pharmacological fMRI.

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Detection of the acute effects of hydrocortisone in the hippocampus using pharmacological fMRI.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Symonds, Catherine S. McKie, Shane Elliott, Rebecca William Deakin, John Francis Anderson, Ian M.
Description	Country affiliation: United kingdom Author Affiliation: Symonds CS ( Neuroscience and Psychiatry Unit, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, United Kingdom. Catherine.Symonds@manchester.ac.uk)
Abstract	Impaired hippocampal function is believed to be important in the pathogenesis of depression. The hippocampus contains a high concentration of both mineralocorticoid (MR) and glucocorticoid receptors (GR), and the experimental administration of corticosteroids has been reported to mimic memory impairments seen in depression. Using pharmacological functional magnetic resonance imaging (phMRI) we investigated whether hippocampal function is altered after acute administration of hydrocortisone. Changes in BOLD signal following infusion of 100mg hydrocortisone given as a rapid intravenous bolus were measured in 14 healthy volunteers in a within-subject placebo-controlled crossover design. Subsequently, subjects completed an n-back task during an fMRI scan. Hydrocortisone infusion caused a significant, time-dependent increase in fMRI BOLD signal in hippocampus reaching a maximal effect at 11-19min. The n-back task increased BOLD signal in prefrontal and parietal cortical areas and decreased it in the hippocampus. After hydrocortisone the left hippocampal decrease in BOLD signal was attenuated with the magnitude of attenuation correlating with the increase seen after hydrocortisone infusion. No difference in behavioural task performance was observed. The results suggest acute hydrocortisone has rapid direct and modulatory influences on hippocampal function, probably acting through non-genomic GR or MR signalling. Hydrocortisone infusion phMRI may be a useful tool to investigate hippocampal corticosteroid receptor function in depression.
File Format	HTM / HTML
ISSN	0924977X
Issue Number	12
Volume Number	22
e-ISSN	18737862
Journal	European Neuropsychopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-12-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychopharmacology Hippocampus Drug Effects Physiology Hydrocortisone Administration & Dosage Magnetic Resonance Imaging Methods Adult Cross-over Studies Female Metabolism Humans Male Neural Pathways Psychomotor Performance Single-blind Method Time Factors Young Adult Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neurology Biological Psychiatry Neurology (clinical) Pharmacology Pharmacology (medical) Psychiatry and Mental Health

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