NDLI: Calciphylaxis due to hyperparathyroidism.

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Medical management of postsurgical hypoparathyroidism.

The parathyroid hormone assay.

Subtotal parathyroidectomy for primary hyperparathyroidism.

Medications that affect calcium.

Significance of elevated parathyroid hormone after parathyroidectomy for primary hyperparathyroidism.

Cost-effectiveness of parathyroidectomy for primary hyperparathyroidism.

Contemporary and practical uses of intraoperative parathyroid hormone monitoring.

Lithium use and primary hyperparathyroidism.

Parathyroid autotransplantation.

Surgical treatment of primary hyperparathyroidism.

Calciphylaxis due to hyperparathyroidism.

The parathyroid glands: what the endocrine surgeon should know.

Parathyroid cancer.

Vitamin D receptors and parathyroid glands.

Benign familial hypocalciuric hypercalcemia.

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Calciphylaxis due to hyperparathyroidism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roy, Rashmi Lee, James A.
Description	Country affiliation: United States Author Affiliation: Roy R ( Department of Endocrine Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA. rroy2@jhmi.edu)
Abstract	OBJECTIVE: To discuss when and how to workup calciphylaxis for early diagnosis and to delineate medical vs surgical management of the disease. METHODS: Review of evidence-based medical literature on calciphylaxis due to primary, secondary, and tertiary hyperparathyroidism. RESULTS: Calciphylaxis is usually associated with secondary and tertiary hyperparathyroidism. However, calciphylaxis can also be seen in the absence of chronic renal failure and has been reported in patients with primary hyperparathyroidism due to a parathyroid adenoma or carcinoma. Calciphylaxis occurs when the levels of calcium and phosphate in the blood exceed their solubility level, leading to calcium-phosphate deposits in arteries that compromise the vasculature. These ischemic changes result in plaque-like lesions that progress to painful nodules. Calciphylaxis is diagnosed on the basis of physical examination, laboratory, and histopathologic findings. When medical therapy has failed in the setting of secondary/tertiary hyperparathyroidism with calciphylaxis, parathyroidectomy is the preferred treatment. In primary hyperparathyroidism, early recognition and aggressive wound care with debridement are important in managing this condition. However, resection of the offending parathyroid gland should be strongly considered. CONCLUSIONS: When calciphylaxis is present, early detection is critical to the successful management of this condition. Although medical therapy can be effective, surgical resection of the diseased parathyroid glands can be curative and potentially life saving. A multidisciplinary approach involving early diagnosis, aggressive medical management, operative debridement, and parathyroidectomy has the best chance of improving survival in calciphylaxis.
File Format	HTM / HTML
ISSN	1530891X
Issue Number	Suppl 1
Journal	Endocrine Practice
Volume Number	17
e-ISSN	19342403
Language	English
Publisher	American Association of Clinical Endocrinologists
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Calciphylaxis Diagnosis Etiology Hyperparathyroidism Complications Surgery Humans Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology

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