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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Al-Sayed, Nasreen A. Gao, Tianming Wells, Brian J. Yu, Changhong Zimmerman, Robert S. |
| Description | Country affiliation: United States Author Affiliation: Al-Sayed NA ( Department of Endocrinology and Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. n_alsayed@hotmail.com) |
| Abstract | OBJECTIVE: This study retrospectively compared the effects of angiotensin-converting enzyme inhibitors (ACEIs) versus angiotensin receptor blockers (ARBs) as classes with respect to overall mortality and cardiovascular and renal events in patients with type 2 diabetes. METHODS: An electronic database of medical records was reviewed. A total of 16,489 patients with type 2 diabetes were enrolled and divided into ACEI (n = 12,351) or ARB (n = 4,138) groups. Baseline patient characteristics were compared using univariable analysis. A chi-square test was used for categorical outcomes, and the propensity class was calculated using multivariable logistic regression. Survival analysis was performed to evaluate the effect of ACEIs/ARBs on overall survival, coronary artery disease (CAD), and renal events via Cox regression analysis, adjusting for propensity class and baseline variables. All statistical analyses were conducted using R 2.15.1 software. RESULTS: No significant differences in overall survival (P = .16) and CAD (P = .81) events were observed between groups. With respect to renal events, ARBs increased the risk of creatinine doubling compared with ACEIs, but the difference was not significant (hazard ratio [HR], 1.207; 95% confidence interval [CI], 0.921-1.583; P = .173). Patients who received ARBs had a significantly higher rate of albuminuria than patients who received ACEIs (HR, 1.303; 95% CI, 1.053-1.612; P = .015). CONCLUSION: The early effects of ACEIs and ARBs on albuminuria outcome seem to be different in type 2 diabetes, favoring the use of ACEIs. A well-designed prospective study is warranted to evaluate this finding. |
| File Format | HTM / HTML |
| ISSN | 1530891X |
| Issue Number | 4 |
| Volume Number | 19 |
| e-ISSN | 19342403 |
| Journal | Endocrine Practice |
| Language | English |
| Publisher | American Association of Clinical Endocrinologists |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology Albuminuria Drug Therapy Angiotensin Receptor Antagonists Therapeutic Use Angiotensin-converting Enzyme Inhibitors Diabetes Mellitus, Type 2 Adult Aged Female Humans Male Middle Aged Retrospective Studies Treatment Outcome Young Adult Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology |
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