NDLI: Role of antisecretory agents for gastric endoscopic submucosal dissection.

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Year: 2012 Volume: 24

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Role of antisecretory agents for gastric endoscopic submucosal dissection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fujishiro, Mitsuhiro Chiu, Philip W. Y. Wang, Hsui-Po
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Fujishiro M ( Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. mtfujish-kkr@umin.ac.jp)
Abstract	Gastric endoscopic submucosal dissection (ESD) causes artificial gastric ulcers and there is no consensus regarding the optimal perioperative management in terms of prevention of intra- or postoperative bleeding and promotion of healing. Traditionally, 8-week administration of proton pump inhibitors (PPI) and mucosal protective agents were used in the same way as for peptic ulcer management. However, recent studies have revealed that prior use of PPI might reduce intraoperative bleeding or early-phase postoperative bleeding, and combination of histamine-2 receptor antagonist (H2RA), and second-look endoscopy might have a similar effect on postoperative bleeding to PPI. Additionally, the advantage of PPI over H2RA is not proven and the optimal duration of PPI may be shortened until 2 weeks when the deteriorating factors for ESD ulcer are excluded. Furthermore, mucosal protective agents may facilitate ulcer healing. Further studies are needed to determine the optimal treatment protocol before and after ESD for both prevention of bleeding complication and promotion of ulcer healing, by using available antisecretory agents and mucosal protective agents.
File Format	HTM / HTML
ISSN	09155635
Issue Number	Suppl 1
Volume Number	25
e-ISSN	14431661
Journal	Digestive Endoscopy
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-03-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Diagnostic Imaging Discipline General Surgery Discipline Gastroenterology Dissection Methods Gastric Mucosa Surgery Gastroscopy Histamine H2 Antagonists Administration & Dosage Peptic Ulcer Hemorrhage Prevention & Control Perioperative Care Postoperative Complications Postoperative Hemorrhage Proton Pump Inhibitors Stomach Neoplasms Stomach Ulcer Drug Administration Schedule Electrocoagulation Follow-up Studies Blood Supply Drug Effects Pathology Adverse Effects Humans Japan Microvessels Preoperative Care Reoperation Risk Factors Sucralfate Surgical Instruments Wound Healing Comparative Study Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Gastroenterology

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