NDLI: Oral, esophageal and cutaneous lichen ruber planus controlled with alitretinoin: case report and review of the literature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kolios, Antonios G. A. Marques Maggio, Ewerton Gubler, Christoph Cozzio, Antonio Dummer, Reinhard French, Lars E. Navarini, Alexander A.
Description	Country affiliation: Switzerland Author Affiliation: Kolios AG ( Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.)
Abstract	BACKGROUND: Therapy-resistant lichen planus (LP) can be a challenging condition for dermatologists. There are some case reports about successful treatments with alitretinoin of cutaneous and oral, but not of esophageal LP. OBJECTIVE: We present the unique case of a patient with cutaneous, oral and esophageal LP which was refractory to classical treatment options (topical clobetasol propionate and pimecrolimus, intramuscular triamcinolone acetonide); because of systemic side effects the patient did not tolerate systemic acitretin dosed up to 25 mg daily. METHODS: Oral alitretinoin was used at a dose of 30 mg daily. RESULTS: Both oral and skin changes as well as dysphagia completely resolved within 4 weeks without any severe side effects and the drug was used for 6 months. No papules, intraoral striae or dysphagia recurred during the 6 months of treatment. After 4 months the patient relapsed with mucosal patches so that a second cycle was initiated for 6 months where oral LP lesions resolved after 4 weeks also (with sporadic mild headache). CONCLUSION: Further studies are needed to better understand the impact of alitretinoin in LP. Our observation suggests alitretinoin as a new, well-tolerated treatment option for esophageal LP after failed response to conventional treatments.
File Format	HTM / HTML
ISSN	10188665
e-ISSN	14219832
Journal	Dermatology
Issue Number	4
Volume Number	226
Language	English
Publisher	Karger
Publisher Date	2013-01-01
Publisher Place	Switzerland
Access Restriction	Open
Subject Keyword	Discipline Dermatology Antineoplastic Agents Therapeutic Use Esophageal Diseases Drug Therapy Lichen Planus Tretinoin Deglutition Disorders Etiology Complications Pathology Lichen Planus, Oral Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Case study Article
Subject	Dermatology

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