NDLI: The spectrum of acute heart failure after venlafaxine overdose.

Please wait, while we are loading the content...

Year: 2017 Volume: 55

Year: 2016 Volume: 54

Year: 2015 Volume: 53

Year: 2014 Volume: 52

Year: 2013 Volume: 51

Year: 2013 Volume: 51 Issue: 10

Year: 2013 Volume: 51 Issue: 9

Year: 2013 Volume: 51 Issue: 8

Year: 2013 Volume: 51 Issue: 7

Year: 2013 Volume: 51 Issue: 6

Year: 2013 Volume: 51 Issue: 5

Year: 2013 Volume: 51 Issue: 4

Year: 2013 Volume: 51 Issue: 3

Year: 2013 Volume: 51 Issue: 2

Harmonisation of product notification to Poisons Centres in EU Member States.

The spectrum of acute heart failure after venlafaxine overdose.

Determining the volume of toxic liquid ingestions in adults: accuracy of estimates by healthcare professionals and members of the public.

Envenomation by the Great Lakes Bush Viper (Atheris nitschei).

Indicators for serious kidney complications associated with toxic exposures: an analysis of the National Poison Data System.

Response to the letter 'Risk assessment of methanol poisoning in outbreaks not applicable to isolated cases'.

A retrospective review of isolated duloxetine-exposure cases.

C-reactive protein value in organophosphate-poisoned patients - Promises and pitfalls.

Severe adverse effects related to dermal exposure to a glyphosate-surfactant herbicide.

The perception of odor is not a surrogate marker for chemical exposure: a review of factors influencing human odor perception.

Cross-reactivity studies and predictive modeling of 'Bath Salts' and other amphetamine-type stimulants with amphetamine screening immunoassays.

Year: 2013 Volume: 51 Issue: 1

Year: 2012 Volume: 50

Year: 2011 Volume: 49

Year: 2010 Volume: 48

Year: 2009 Volume: 47

Year: 2008 Volume: 46

Year: 2007 Volume: 45

Year: 2006 Volume: 44

Year: 2005 Volume: 43

The spectrum of acute heart failure after venlafaxine overdose.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Batista, M. Dugernier, T. Simon, M. Haufroid, V. Capron, A. Fonseca, S. Bonbled, F. Hantson, P.
Description	Country affiliation: Belgium Author Affiliation: Batista M ( Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium.)
Abstract	OBJECTIVE: Venlafaxine is a bicyclic antidepressant that may be associated with severe cardiotoxicity following large overdose. The purpose of this short case series is to present different patterns of venlafaxine-related cardiotoxicity and to discuss the potential mechanisms. CASE SERIES: Between January 2010 and July 2011, four patients were admitted to an ICU with acute left ventricular failure following large venlafaxine overdoses. The age of the four female patients ranged from 35 to 65 years. None of them had no history of cardiovascular disease. The amount of venlafaxine ingested by history ranged from 3150 to 13500 mg (extended-release preparation in two cases). The peak serum venlafaxine concentration was between 2153.3 and 9950 ng/ml. Three patients died and one recovered rapidly. The initial ECG revealed only mild abnormalities in two cases. In two patients, at least one ECG recording demonstrated a widening of QRS interval. In three patients, echocardiography disclosed a left ejection fraction of 15%-18%. Two patients presented a severe serotonin syndrome, with major rhabdomyolysis. Seizures were noted in two cases, including one patient with status epilepticus. Three patients were mechanically ventilated. The causes of death were refractory hypoxemia, malignant arrhythmias, and cardiogenic shock, respectively. DISCUSSION: Severe and diffuse left ventricular dysfunction may be observed after large venlafaxine overdoses and this is not always associated with severe cardiac conduction function abnormalities. The mechanisms underlying venlafaxine-related cardiac failure with preserved normal cardiac conduction are discussed. A possible explanation may be a catecholamine-induced myocardial damage in relationship with the inhibition of norepinephrine (and dopamine) reuptake.
File Format	HTM / HTML
ISSN	15563650
Issue Number	2
Volume Number	51
e-ISSN	15569519
Journal	Clinical Toxicology
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Antidepressive Agents, Second-generation Poisoning Cyclohexanols Heart Failure Chemically Induced Acute Disease Adult Aged Death, Sudden, Cardiac Etiology Delayed-action Preparations Electrocardiography Epilepsy, Tonic-clonic Complications Fatal Outcome Female Physiopathology Humans Anoxia Long Qt Syndrome Middle Aged Respiration, Artificial Serotonin Syndrome Shock, Cardiogenic Stroke Volume Drug Effects Suicide, Attempted Venlafaxine Hydrochloride Ventricular Function, Left Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Medicine Toxicology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in