NDLI: Diacylglycerol-induced improvement of whole-body insulin sensitivity in type 2 diabetes mellitus: a long-term randomized, double-blind controlled study.

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Year: 2008 Volume: 27 Issue: 1

Year: 2007 Volume: 26

Diacylglycerol-induced improvement of whole-body insulin sensitivity in type 2 diabetes mellitus: a long-term randomized, double-blind controlled study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Duo Xu, Tongcheng Takase, Hideto Tokimitsu, Ichiro Zhang, Pianhong Wang, Qingqing Yu, Xiaomei Zhang, Aizhen
Description	Country affiliation: China Author Affiliation: Li D ( Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou, Zhejiang 310029, China. duoli@zju.edu.cn)
Abstract	BACKGROUND & AIMS: Diacylglycerol oil has been shown to lower postprandial and fasting serum triacylglycerol levels and reduce body fat. The aim of this study was to investigate the effect of diacylglycerol oil on risk factors of type 2 diabetes mellitus (DM) and cardiovascular disease in type 2 DM patients. METHODS: This was a double-blind controlled parallel study with 127 type 2 DM patients (aged 40-65) recruited in Hangzhou, China. All subjects consumed triacylglycerol oil in the lead-in period (14 days), then they were randomly divided into two groups and consumed diacylglycerol or triacylglycerol oil with a similar fatty acid composition (25 g/day) for 120 days. Blood samples were collected on days 0, 60 and 120 and risk factors of type 2 DM and cardiovascular disease and biochemical parameters were measured by standard methods. RESULTS: There were a total of 112 subjects who completed the study. Diet intake did not differ significantly between groups. Body weight, BMI, waist circumference, HOMA-IR, serum insulin and leptin levels were significantly reduced from baseline in the diacylglycerol oil group but not in the triacylglycerol oil group. Serum glucose was also significantly improved in patients with higher glucose levels at baseline (>7.00 mmol/L) in the diacylglycerol oil group. Parameters of liver and kidney functions and essential fatty acids in serum phospholipids did not differ between groups. CONCLUSIONS: Diacylglycerol oil consumption improved biomarkers and anthropometric parameters of type 2 DM compared with triacylglycerol oil. No adverse reactions were observed with diacylglycerol oil consumption for type 2 DM patients. Diacylglycerol oil has an equivalent bioavailability as triacylglycerol oil in relation to providing essential fatty acids.
File Format	HTM / HTML
ISSN	02615614
Issue Number	2
Volume Number	27
e-ISSN	15321983
Journal	Clinical Nutrition
Language	English
Publisher	Elsevier
Publisher Date	2008-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nutritional Sciences Blood Glucose Metabolism Cardiovascular Diseases Diet Therapy Diabetes Mellitus, Type 2 Diglycerides Pharmacology Insulin Adult Aged Biological Markers Blood Body Mass Index Body Weight Drug Effects Physiology Administration & Dosage Double-blind Method Female Humans Hypertriglyceridemia Male Middle Aged Obesity Risk Factors Treatment Outcome Triglycerides Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Critical Care and Intensive Care Medicine

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