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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pang, Ji Guo, Jin-peng Jin, Min Chen, Zhi-qiang Wang, Xin-wei Li, Jun-Wen |
| Description | Country affiliation: China Author Affiliation: Pang J ( Institution of Healthy and Toxicology, Beijing Centers for Disease Prevention and Control, Beijing, China.) |
| Abstract | OBJECTIVE: To investigate the antiviral effects of the aqueous extract of Spatholobus suberectus Dunn. (A.E.), a Chinese medicinal herb, against coxsackievirus B3 (CVB3). METHODS: The antiviral effects of A.E. against CVB3 in vitro (primarily cultured myocardial cells) and in vivo (BALB/c mice) were determined. Serum pharmacological method was also adopted by in vitro experiments. The effects of A.E. inhibiting the CVB3 mRNA expression were compared by RT-PCR in mice in vivo. RESULTS: A.E. exhibited obvious antiviral: effects in vivo, and serum samples obtained from the rats with oral administration of A.E. (10 µg/mL, 5 µg/mL), reduced the virus titers in the infected myocardial cells (3.00±0.70, 3.55±0.52, P<0.01). Meanwhile, the viral myocarditis induced by CVB3 was inhibited significantly by A.E., and the 15-day mortality was reduced to 40% and 45% (P<0.01) in mice treated with A.E. at doses of 50 mg/kg and 100 mg/kg, respectively, while the 30-day mortality was decreased to 45% and 50%, respectively (P<0.01). Moreover, the mRNA expression of Coxsackie virus B3 was significantly inhibited by A.E. CONCLUSION: Aqueous extract of Spatholobus suberectus Dunn. (A.E.) has inhibitory effect on CVB3 both in vitro and in vivo. |
| File Format | HTM / HTML |
| ISSN | 16720415 |
| Issue Number | 10 |
| Volume Number | 17 |
| e-ISSN | 19930402 |
| Journal | Chinese Journal of Integrative Medicine |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2011-10-01 |
| Publisher Place | China |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Antiviral Agents Pharmacology Therapeutic Use Coxsackievirus Infections Drug Therapy Virology Enterovirus Drug Effects Fabaceae Chemistry Plant Extracts Animals Body Weight Cercopithecus Aethiops Blood Pathology Gene Expression Regulation Male Mice Mice, Inbred Balb C Myocardium Organ Size Phytotherapy Rna, Messenger Genetics Metabolism Rats Rats, Sprague-dawley Reverse Transcriptase Polymerase Chain Reaction Survival Analysis Vero Cells Viral Load Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Complementary and Alternative Medicine |
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