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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tong, Guang-Dong Tang, Hai-Hong Wei, Chun-Shan Chen, Ying-Jie He, Jin-Song Zhou, Xiao-Zhou Zheng, Ying-Jun Zhou, Da-Qiao |
| Description | Country affiliation: China Author Affiliation: Tong GD ( Department of Liver Disease, Shenzhen Hospital Affiliated to Guangzhou University of Chinese Medicine, Shenzhen, Guangdong Province, 518033, China.) |
| Abstract | OBJECTIVE: To observe the efficacy of ursodeoxycholic acid (UDCA) combined with Tongdan: Decoction () on immunological indices and histopathological changes in patients with primary biliary cirrhosis (PBC) of IIor III histological stage. METHODS: Sixty PBC patients were assigned randomly and equally: to the control group treated with UDCA alone and the treatment group treated with UDCA combined with Tongdan Decoction. The immunological indices and histopathological changes were detected before and after 24-week treatment, and the follow-up lasted for 1-3 years. RESULTS: After 24-week treatment, CD4(+)CD28(-) in the peripheral blood was lowered and CD4(+)CD25(+) was increased in both groups, and better effect was shown in the treatment group (P<0.01). The levels of IgM, IgG, and IgA decreased markedly after 96-week treatment in the treatment group (P< 0.05, P< 0.01), while in the control group, only the latter two showed significant decrease after 148 week (all P<0.05). At the end of the 3-year follow-up, the medians of histopathological |
| File Format | HTM / HTML |
| ISSN | 16720415 |
| Issue Number | 1 |
| Volume Number | 18 |
| e-ISSN | 19930402 |
| Journal | Chinese Journal of Integrative Medicine |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-01-01 |
| Publisher Place | China |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Drugs, Chinese Herbal Therapeutic Use Liver Cirrhosis, Biliary Drug Therapy Pathology Ursodeoxycholic Acid Antigens, Cd Blood Biological Markers Drug Therapy, Combination Female Humans Immunoglobulin G Inflammation Complications Immunology Male Middle Aged Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Complementary and Alternative Medicine |
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