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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Shu-Yu Zhao, Neng-Jiang Li, Xue-Jun Zhang, Hui-Jie Chen, Ke-Ji Li, Can-Dong |
| Description | Country affiliation: China Author Affiliation: Yang SY ( Post-Graduate School, Fujian University of Traditional Chinese Medicine, Fuzhou, China.) |
| Abstract | OBJECTIVE: To investigate the therapeutic effects of Ping-tang Recipe (, PTR) on high-fat diet (HFD)-induced insulin resistance and non-alcoholic fatty liver disease (NAFLD), and to elucidate the underlying mechanisms. METHODS: Forty male SD rats were included in the study. Ten rats were fed on normal diet as normal control, and thirty rats were fed on HFD for 8 weeks to induce obesity, followed with low dose (0.42 g/kg) or high dose (0.84 g/kg) of PTR or vehicle for 8 weeks with 10 animals for each group. Glucose metabolism and insulin sensitivity were evaluated by oral glucose tolerance test and insulin tolerance test. Hepatic steatosis was measured by immunohistochemistry. Liver lipid metabolic genes were analyzed by quantitative real-time polymerase chain reaction, while AMP-activated protein kinase (AMPK) expression was examined by Western blot. RESULTS: Rats fed on HFD developed abdominal obesity, insulin resistance and NAFLD. PTR treatment reduced visceral fat (peri-epididymal and peri-renal) accumulation, improved glucose metabolism, and attenuated hepatic steatosis. The expressions of the key lipolytic regulating genes, including peroxisome proliferators-activated receptor γ co-activator 1 (PGC-1 ), peroxisome proliferator-activated receptor γ (PRAR-γ) and (PRAR- ), were up-regulated (P<0.05 or P<0.01), while the expressions of lipogenic genes such as sterol regulatory element-binding protein 1c (SREBP-1c), fatty acid synthase (FAS) and liver fatty acid-binding protein (L-FABP) were down-regulated (P<0.05 or P<0.01). In addition, PTR activated AMPK and promoted acetyl-CoA carboxylase phosphorylation in the liver. CONCLUSIONS: PTR improves insulin resistance and reverse hepatic steatosis in the rat model of HFD-induced obesity through promotion of lipolysis and reduction of lipogenesis, which involves the AMPK signaling pathway, thus representing a new therapeutic intervention for obesity related insulin resistance and NAFLD. |
| File Format | HTM / HTML |
| ISSN | 16720415 |
| Issue Number | 4 |
| Volume Number | 18 |
| e-ISSN | 19930402 |
| Journal | Chinese Journal of Integrative Medicine |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-04-01 |
| Publisher Place | China |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Diet, High-fat Drugs, Chinese Herbal Therapeutic Use Fatty Liver Complications Prevention & Control Insulin Resistance Obesity Amp-activated Protein Kinases Metabolism Animals Body Weight Drug Effects Pharmacology Blood Gene Expression Regulation Glucose Glucose Tolerance Test Intra-abdominal Fat Pathology Lipogenesis Lipolysis Liver Enzymology Male Rna, Messenger Genetics Rats Rats, Sprague-dawley Triglycerides Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Complementary and Alternative Medicine |
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