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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Ran Cong, Wei-hong Guo, Gang Li, Xiang-xin Chen, Xue-liang Yu, Xiao-ning Li, Hao |
| Description | Country affiliation: China Author Affiliation: Wang R ( Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, China.) |
| Abstract | OBJECTIVE: To investigate the synergistic effects of carnosic acid (CA) with arsenic trioxide (As2O3) on proliferation and apoptosis in HL-60 human myeloid leukemia cells, and the major cellular signaling pathway involved in these effects. METHODS: HL-60 cellular proliferation was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis. Cell cycle distribution and apoptosis were monitored by flow cytometry. The activation of casepase-9, Bcl-2-associated agonist of cell death (BAD), p-BAD, p27, phosphatase and tensin homolog deleted on chromosome ten (PTEN), Akt, p-Akt was assessed by Western blot analysis. The expression of PTEN mRNA was tested by reverse transcription polymerase chain reaction (RT-PCR) analysis. RESULTS: CA reduced HL-60 cell viability in a dose- and time-dependent manner, and induced G1 arrest and apoptosis. Moreover, CA upregulated PTEN expression, blocked the Akt signaling pathway, subsequently inhibited phosphorylation of BAD, reactivated caspase-9, and elevated levels of p27. CA also augmented these effects of As2O3. CONCLUSION: CA might be a novel candidate of the combination therapy for leukemia treatment; these effects were apparently associated with the modulation of PTEN/Akt signaling pathway. |
| File Format | HTM / HTML |
| ISSN | 16720415 |
| Issue Number | 12 |
| Volume Number | 18 |
| e-ISSN | 19930402 |
| Journal | Chinese Journal of Integrative Medicine |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-12-01 |
| Publisher Place | China |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Apoptosis Drug Effects Arsenicals Pharmacology Diterpenes, Abietane Leukemia, Myeloid, Acute Pathology Oxides Pten Phosphohydrolase Metabolism Plant Extracts Proto-oncogene Proteins C-akt Signal Transduction Base Sequence Blotting, Western Cell Cycle Dna Primers Drug Synergism Hl-60 Cells Humans Reverse Transcriptase Polymerase Chain Reaction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Complementary and Alternative Medicine |
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