NDLI: The absorption and transport of magnolol in Caco-2 cell model.

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The absorption and transport of magnolol in Caco-2 cell model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, An-Guo Zeng, Bao Huang, Meng-Qiu Li, Sheng-Mei Chen, Jian-Nan Lai, Xiao-Ping
Description	Country affiliation: China Author Affiliation: Wu AG ( Research Center of New Drug Development, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.)
Abstract	OBJECTIVE: To investigate the absorption and transport mechanism of magnolol in Caco-2 cell model. METHODS: A human intestinal epithelial cell model Caco-2 cell in vitro cultured was applied to study the absorption and transport of magnolol, the effects of time, donor concentration, P-gp inhibitor verapamil, pH and temperature on the absorption and transport of magnolol were investigated. The determination of magnolol was performed by high performance liquid chromatography, then the values of apparent permeability coefficient (P app ) and P ratio Basolateral-to-Apical (BL-to-AP)/Apical-to-Basolateral (AP-to-BL) were calculated. RESULTS: In Caco-2 cell model, comparing the amounts of transport of AP-to-BL and BL-to-AP, the latter was larger. At the same donor concentration, either the amounts of transport of AP-to-BL or BL-to-AP increased with increase in donor concentration and incubation time. Verapamil could significantly improve the amounts of transport of AP-to-BL. The transport of AP-to-BL and BL-to-AP depended on temperature, and there was no significant effect of pH on the transport of AP-to-BL. CONCLUSION: Magnolol could be transported through the intestinal mucosa via a passive diffusion mechanism primarily, coexisting with a carrier-mediated transport, at the same time, the efflux mechanism could be involved.
File Format	HTM / HTML
ISSN	16720415
Issue Number	3
Volume Number	19
e-ISSN	19930402
Journal	Chinese Journal of Integrative Medicine
Language	English
Publisher	Springer
Publisher Date	2013-03-01
Publisher Place	China
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Therapeutics Biphenyl Compounds Metabolism Intestinal Absorption Lignans Models, Biological Biological Transport Drug Effects Caco-2 Cells Chromatography, High Pressure Liquid Humans Hydrogen-ion Concentration Temperature Time Factors Verapamil Pharmacology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Complementary and Alternative Medicine

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