NDLI: Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era.

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Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Joshu, Corinne E. Mondul, Alison M. Menke, Andy Meinhold, Cari Han, Misop Humphreys, Elizabeth B. Freedland, Stephen J. Walsh, Patrick C. Platz, Elizabeth A.
Description	Country affiliation: United States Author Affiliation: Joshu CE ( Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Rm. E6137, Baltimore, MD 21205, USA. cjoshu@jhsph.edu)
Abstract	Although obesity at the time of prostatectomy has been associated with prostate cancer recurrence, it is unknown whether obesity before or after surgery, or weight change from the years prior to surgery to after surgery is associated with recurrence. Thus, we examined the influence of obesity and weight change on recurrence after prostatectomy. We conducted a retrospective cohort study of 1,337 men with clinically localized prostate cancer who underwent prostatectomy performed during 1993-2006 by the same surgeon. Men self-reported weight and physical activity at 5 years before and 1 year after surgery on a survey during follow-up. Mean follow-up was 7.3 years. We estimated multivariable-adjusted HRs of prostate cancer recurrence comparing obesity at 5 years before and at 1 year after surgery with normal weight, and a gain of more than 2.2 kg from 5 years before to 1 year after surgery with stable weight. During 9,797 person years of follow-up, 102 men recurred. Compared with men who had stable weight, those whose weight increased by more than 2.2 kg had twice the recurrence risk (HR = 1.94; 95% CI, 1.14-3.32) after taking into account age, pathologic stage and grade, and other characteristics. The HR of recurrence was 1.20 (95% CI, 0.64-2.23) and 1.72 (95% CI, 0.94-3.14) comparing obesity at 5 years before and at 1 year after surgery, respectively, with normal weight. Physical activity (≥ 5 h/wk) did not attenuate risk in men who gained more than 2.2 kg. By avoiding weight gain, men with prostate cancer may both prevent recurrence and improve overall well-being.
File Format	HTM / HTML
ISSN	19406207
e-ISSN	19406215
DOI	10.1158/1940-6207.CAPR-10-0257
Journal	Cancer Prevention Research
Issue Number	4
Volume Number	4
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2011-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Oncology Neoplasm Recurrence, Local Etiology Obesity Complications Prostatic Neoplasms Weight Gain Physiology Body Mass Index Cohort Studies Pathology Surgery Prostate-specific Antigen Blood Prostatectomy Retrospective Studies Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era.