NDLI: A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma.

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A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rotunno, Melissa Hu, Nan Su, Hua Wang, Chaoyu Goldstein, Alisa M. Bergen, Andrew W. Consonni, Dario Pesatori, Angela C. Bertazzi, Pier Alberto Wacholder, Sholom Shih, Joanna Caporaso, Neil E. Taylor, Phil R. Landi, Maria Teresa
Description	Country affiliation: United States Author Affiliation: Rotunno M ( Division of Cancer Epidemiology and Genetics, NCI, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA.)
Abstract	Affordable early screening in subjects with high risk of lung cancer has great potential to improve survival from this deadly disease. We measured gene expression from lung tissue and peripheral whole blood (PWB) from adenocarcinoma cases and controls to identify dysregulated lung cancer genes that could be tested in blood to improve identification of at-risk patients in the future. Genome-wide mRNA expression analysis was conducted in 153 subjects (73 adenocarcinoma cases, 80 controls) from the Environment And Genetics in Lung cancer Etiology study using PWB and paired snap-frozen tumor and noninvolved lung tissue samples. Analyses were conducted using unpaired t tests, linear mixed effects, and ANOVA models. The area under the receiver operating characteristic curve (AUC) was computed to assess the predictive accuracy of the identified biomarkers. We identified 50 dysregulated genes in stage I adenocarcinoma versus control PWB samples (false discovery rate ≤0.1, fold change ≥1.5 or ≤0.66). Among them, eight (TGFBR3, RUNX3, TRGC2, TRGV9, TARP, ACP1, VCAN, and TSTA3) differentiated paired tumor versus noninvolved lung tissue samples in stage I cases, suggesting a similar pattern of lung cancer-related changes in PWB and lung tissue. These results were confirmed in two independent gene expression analyses in a blood-based case-control study (n = 212) and a tumor-nontumor paired tissue study (n = 54). The eight genes discriminated patients with lung cancer from healthy controls with high accuracy (AUC = 0.81, 95% CI = 0.74-0.87). Our finding suggests the use of gene expression from PWB for the identification of early detection markers of lung cancer in the future.
File Format	HTM / HTML
ISSN	19406207
e-ISSN	19406215
DOI	10.1158/1940-6207.CAPR-10-0170
Journal	Cancer Prevention Research
Issue Number	10
Volume Number	4
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2011-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Oncology Adenocarcinoma Genetics Pathology Tumor Markers, Biological Blood Gene Expression Profiling Lung Neoplasms Case-control Studies Neoplasm Grading Neoplasm Staging Oligonucleotide Array Sequence Analysis Roc Curve Comparative Study Research Support, N.i.h., Intramural
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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