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Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Razzak, Anthony A. Oxentenko, Amy S. Vierkant, Robert A. Tillmans, Lori S. Wang, Alice H. Weisenberger, Daniel J. Laird, Peter W. Lynch, Charles F. Anderson, Kristin E. French, Amy J. Haile, Robert W. Harnack, Lisa J. Slager, Susan L. Smyrk, Thomas C. Thibodeau, Stephen N. Cerhan, James R. Limburg, Paul J.
Spatial Coverage	Iowa
Description	Country affiliation: United States Author Affiliation: Razzak AA ( Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.)
Abstract	Increased alcohol consumption is a putative colorectal cancer (CRC) risk factor. However, existing data are less conclusive for women than men. Also, to date, relatively few studies have reported alcohol-related CRC risks based on molecularly defined tumor subtypes. We evaluated associations between alcohol intake and incident CRC, overall and by microsatellite instability [MSI high (MSI-H) or MSI low/microsatellite stable (MSI-L/MSS)], CpG island methylator phenotype (CIMP positive or CIMP negative), and BRAF mutation (mutated or wild-type) status in the prospective, population-based Iowa Women's Health Study (IWHS; n = 41,836). Subjects were 55 to 69 years at baseline (1986), and exposure data were obtained by self-report. Incident CRCs were prospectively identified and archived, paraffin-embedded tissue specimens were collected from 732 representative cases, diagnosed through December 31, 2002. Multivariate Cox regression models were fit to estimate relative risks (RR) and 95% confidence intervals (CI). Among alcohol consumers, the median intake (range) was 3.4 (0.9-292.8) g/d. Compared with nonconsumers, alcohol intake levels of 3.4 g/d or less (RR = 1.00; 95% CI, 0.86-1.15) and more than 3.4 g/d (RR = 1.06; 95% CI, 0.91-1.24) were not significantly associated with overall CRC risk. Analyses based on alcohol intake levels of 30 g/d or less and more than 30 g/d or quartile distributions yielded similar risk estimates. Null associations were also observed between each alcohol intake level and the MSI-, CIMP- or, BRAF-defined CRC subtypes (P > 0.05 for each comparison). These data do not support an adverse effect from alcohol intake on CRC risk, overall or by specific molecularly defined subtypes, among older women.
File Format	HTM / HTML
ISSN	19406207
e-ISSN	19406215
DOI	10.1158/1940-6207.CAPR-11-0276
Journal	Cancer Prevention Research
Issue Number	12
Volume Number	4
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2011-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Oncology Alcohol Drinking Adverse Effects Colorectal Neoplasms Classification Epidemiology Mutation Genetics Proto-oncogene Proteins B-raf Etiology Cpg Islands Dna Methylation Iowa Microsatellite Instability Prognosis Prospective Studies Risk Factors Randomized Controlled Trial Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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