NDLI: Anticoagulation of a patient with hypertrophic cardiomyopathy and factor VII deficiency.

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Anticoagulation of a patient with hypertrophic cardiomyopathy and factor VII deficiency.

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Anticoagulation of a patient with hypertrophic cardiomyopathy and factor VII deficiency.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Davidson, Simon J. Turner, Natalie Tillyer, Louise
Description	Country affiliation: United kingdom Author Affiliation: Davidson SJ ( Department of Haematology, Royal Brompton Hospital, London, UK. s.davidson@rbht.nhs.uk)
Abstract	A 50-year-old male patient with hypertrophic cardiomyopathy and atrial fibrillation was anticoagulated, with warfarin following insertion of a cardioverter defibrillator. He became markedly over anticoagulated after standard moderate induction doses of warfarin. His baseline prothrombin time was prolonged and further investigation showed the patient to have a mild factor VII deficiency. He was restarted on low-dose warfarin and successfully stabilized with a target international normalized ratio (INR) of 3.0 (range 2.5-3.5). We used the data from factor VII levels and thrombin generation studies before and after anticoagulation to control dosage and to decide on a suitable therapeutic range for the INR. Molecular studies showed him to have two separate mutations in the factor VII gene. This report highlights the importance of noting the baseline prothrombin time before initiating oral anticoagulation and describes how well tolerated anticoagulation can be achieved in a patient with congenital factor VII deficiency.
File Format	HTM / HTML
ISSN	09575235
Issue Number	7
Volume Number	21
e-ISSN	14735733
Journal	Blood Coagulation & Fibrinolysis
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2010-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Hematology Anticoagulants Therapeutic Use Cardiomyopathy, Hypertrophic Drug Therapy Drug Monitoring Methods Factor Vii Deficiency Atrial Fibrillation Factor Vii Genetics Humans International Normalized Ratio Male Middle Aged Mutation Prothrombin Time Warfarin Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Hematology

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