NDLI: Triglyceride concentration and waist circumference influence alcohol-related plasminogen activator inhibitor-1 activity increase in black South Africans.

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Triglyceride concentration and waist circumference influence alcohol-related plasminogen activator inhibitor-1 activity increase in black South Africans.

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Triglyceride concentration and waist circumference influence alcohol-related plasminogen activator inhibitor-1 activity increase in black South Africans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pieters, Marlien de Lange, Zelda Hoekstra, Tiny Ellis, Suria M. Kruger, Annamarie
Spatial Coverage	South Africa
Description	Country affiliation: South Africa Author Affiliation: Pieters M ( TReNDS Centre of Excellence - Nutrition, North-West University, Potchefstroom, South Africa. marlien.pieters@nwu.ac.za)
Abstract	We investigated the association between alcohol consumption and plasminogen activator inhibitor-1 activity (PAI-1act) and fibrinogen concentration in a black South African population presenting with lower PAI-1act and higher fibrinogen than what is typically observed in white populations. We, furthermore, wanted to investigate the effect of urbanization, sex, central obesity, increased triglycerides, 4G/5G polymorphism (PAI-1 only) and BMI on the association of alcohol with PAI-1act and fibrinogen. Data from 2010 apparently healthy, randomly collected black South African volunteers from the Prospective Urban and Rural Epidemiological (PURE) study were cross-sectionally analyzed. Alcohol consumption was recorded using quantitative food frequency questionnaires and fasting blood samples were collected for biochemical analysis including PAI-1act and fibrinogen. Heavy alcohol consumption is associated with significantly increased PAI-1act, in the total population as well as in the women separately, and tended to be so in men. This alcohol-related PAI-1act increase was observed in volunteers with increased triglycerides and central obesity but not in volunteers with normal levels and waist circumference. Urbanization, the 4G/5G polymorphism and BMI did not affect the association of alcohol with PAI-1act. Moderate alcohol consumption is associated with decreased fibrinogen concentration. Sex and level of urbanization did not affect the association of alcohol with fibrinogen. Fibrinogen decreased in normal and overweight volunteers but not in obese and centrally obese volunteers following moderate alcohol consumption. Triglyceride levels and waist circumference influence alcohol-related PAI-1act increase potentially through modulating adipocyte and triglyceride-induced PAI-1 production. Obesity prevented alcohol-related fibrinogen decrease possibly by counteracting the anti-inflammatory effect of moderate alcohol consumption.
File Format	HTM / HTML
ISSN	09575235
Issue Number	8
Volume Number	21
e-ISSN	14735733
Journal	Blood Coagulation & Fibrinolysis
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2010-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Hematology Alcohol Drinking Blood Plasminogen Activator Inhibitor 1 Triglycerides Waist Circumference Adult African Continental Ancestry Group Epidemiology Cohort Studies Female Fibrinogen Metabolism Humans Male Middle Aged Obesity Risk Factors South Africa Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Hematology

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