NDLI: Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.

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Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Henkhaus, Rebecca S. Gerner, Eugene W. Ignatenko, Natalia A.
Description	Country affiliation: United States Author Affiliation: Henkhaus RS ( Cancer Biology Interdisciplinary Program, Arizona Cancer Center, The University of Arizona, 1515 N. Campbell Ave., Tucson, AZ 85724, USA.)
Abstract	Kallikrein 6 (KLK6) is a trypsin-like serine peptidase whose relevance in various types of cancers is currently being explored. Previous studies have shown that KLK6 mRNA is upregulated in colon and gastric cancers; however, the regulatory mechanisms and phenotypic consequences of this upregulation are largely unknown. Activating K-RAS mutations are common in colon cancer, occurring in approximately 50% of cases. We have recently reported the upregulation of KLK6 mRNA in Caco2 human colon cancer cells stably transfected with a mutant K-RAS allele (K-RAS(G12V)). In this study we examined the pattern of K-RAS-dependent KLK6 expression and secretion in colon cancer cells. Using pharmacological inhibitors of pathways downstream of K-RAS, we could show that the PI3K and p42/44 MAPK pathways play an important role in the induction of KLK6 in mutant K-RAS-expressing colon cancer cells. Increased KLK6 expression enhanced colon cancer cell migration through laminin and Matrigel. Inhibition of KLK6 using small interference RNA treatment or a specific KLK6 antibody in Caco2 cells stably expressing the mutant K-RAS and in SW480 cells carrying a mutation in the K-RAS oncogene resulted in a reduction in invasiveness through cell culture inserts. These data support the oncogenic role of KLK6 in colorectal cancer.
File Format	HTM / HTML
ISSN	14316730
e-ISSN	14374315
DOI	10.1515/BC.2008.087
Journal	Biological Chemistry
Issue Number	6
Volume Number	389
Language	English
Publisher	Walter de Gruyter
Publisher Date	2008-06-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Cell Movement Colonic Neoplasms Pathology Genes, Ras Kallikreins Metabolism Proto-oncogene Proteins P21(ras) Genetics Animals Cell Line, Tumor Collagen Drug Combinations Enzyme Inhibitors Chemistry Pharmacology Gene Expression Regulation, Neoplastic Drug Effects Immunoglobulin G Intracellular Space Secretion Laminin Mice Mitogen-activated Protein Kinase 1 Mitogen-activated Protein Kinase 3 Phosphatidylinositol 3-kinases Proteoglycans Rna, Messenger Rna, Small Interfering Up-regulation
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry Biochemistry Molecular Biology

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Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.