NDLI: Role of leukotriene B4 receptors in rheumatoid arthritis.

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Role of leukotriene B4 receptors in rheumatoid arthritis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mathis, Steven Jala, Venkatakrishna R. Haribabu, Bodduluri
Description	Country affiliation: United States Author Affiliation: Mathis S ( Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville Health Sciences, Louisville, KY 40202, USA.)
Abstract	The purpose of this review is to summarize the role that murine models of arthritis are playing in the understanding of human rheumatoid arthritis and how leukotriene B(4) (LTB(4)) is emerging as an important target in this field. Both the collagen-induced arthritis (CIA) model and the K/BxN serum transfer arthritis model have contributed to outline the potential mechanisms involved in inflammatory arthritis. Indeed, the CIA model has contributed to the development of effective anti-TNFalpha and anti-IL-1beta based treatments for RA that are currently in the clinic. Many recent studies in mouse models have suggested a critical role for LTB(4) and its receptors in the development of inflammatory arthritis. Inhibitors of LTB(4) biosynthesis as well as LTB(4) receptors are protective in mouse models of RA and mice deficient in the LTB(4) biosynthetic enzymes or LTB(4) receptors are resistant to disease development suggesting several promising targets for RA in this pathway.
File Format	HTM / HTML
ISSN	15689972
e-ISSN	18730183
Journal	Autoimmunity Reviews
Issue Number	1
Volume Number	7
Language	English
Publisher	Elsevier
Publisher Date	2007-11-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Immunology Arthritis, Experimental Metabolism Arthritis, Rheumatoid Receptors, Leukotriene B4 Animals Immunology Cytokines Disease Models, Animal Leukotriene B4 Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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