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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ansil, Puthuparampil Nazarudeen Nitha, Anand Prabha, Santhibhavan Prabhakaran Wills, Pallara Janardhanan Jazaira, Vahab Latha, Mukalel Sankunni |
| Description | Country affiliation: India Author Affiliation: Ansil PN ( Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, M. G. University, P.D. Hills. P.O, Kottayam, Kerala-686560, India.) |
| Abstract | OBJECTIVE: To identify the phytochemical constituents of Amorphophallus campanulatus (A. campanulatus) tuber and to evaluate its antioxidant potential through in vitro and in vivo models. METHODS: Phytochemical screening and in vitro antioxidant activities of A. campanulatus tuber n-hexane extract (ACHE) and methanolic extract (ACME) were evaluated using DPPH, hydroxyl radical, reducing power and total antioxidant capacity assays. The total phenolic and flavonoid contents were also investigated. The protective potential of two different doses of ACME (125 and 250 mg/kg) was also evaluated against thioacetamide (TAA) induced oxidative stress in rats. Silymarin used as a standard drug control. Hepatotoxicity was assessed by quantifying the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The antioxidant potential of ACME were also evaluated by the estimation of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (Thiobarbituric acid reactive substances) in hepatic and renal tissues. Histopathologic changes of liver were also evaluated. RESULTS: In vitro studies revealed that ACME has higher antioxidant and radical scavenging activity than ACHE, which may be attributed to its higher phenolic and flavonoid content. ACME significantly prevented the elevation of serum AST, ALT, ALP, LDH, and tissue malondialdehyde levels(P < 0.05). Hepatic and renal GSH, GST, GR, GPx, and catalase levels were remarkably increased by the treatment with the extract. Quantification of histopathological changes also supported the dose dependent protective effects of ACME. CONCLUSIONS: The results do suggest that A. campanulatus tuber could be considered as a potential source of natural antioxidant. |
| File Format | HTM / HTML |
| ISSN | 19957645 |
| e-ISSN | 23524146 |
| Journal | Asian Pacific Journal of Tropical Medicine |
| Issue Number | 11 |
| Volume Number | 4 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-11-01 |
| Publisher Place | China |
| Access Restriction | Open |
| Subject Keyword | Discipline Tropical Medicine Amorphophallus Chemistry Kidney Metabolism Liver Oxidative Stress Drug Effects Plant Extracts Pharmacology Plant Tubers Alanine Transaminase Blood Alkaline Phosphatase Animals Aspartate Aminotransferases Catalase Disease Models, Animal Glutathione Glutathione Peroxidase Glutathione Reductase Glutathione Transferase L-lactate Dehydrogenase Lipid Peroxidation Pathology Rats, Wistar Thioacetamide Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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