NDLI: Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis.

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Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guo, Ying-Lu Viswanathan, Vijay P. Chiang, Han-Sun Choi, Hyung Ki Yip, Andrew Wai Chun Shen, Wei Kopernicky, Vladimir
Spatial Coverage	Asia
Description	Country affiliation: China Author Affiliation: Guo YL ( Andrology Center, Peking University First Hospital, Peking University, Beijing 100009, China.)
Abstract	We evaluated the efficacy and safety of as-needed tadalafil in a diverse clinical population (with varying patient demographics, disease severity, and comorbid medical conditions) of Asian men with erectile dysfunction (ED). An integrated analysis of five double-blind, placebo-controlled trials (N = 1 046) was performed. Patients were randomly assigned to receive 10 mg tadalafil (N = 185), 20 mg tadalafil (N = 510), or placebo (N = 351). Efficacy assessments included the International Index of Erectile Function (IIEF), Sexual Encounter Profile (SEP) diary and Global Assessment Question (GAQ). Patients receiving 10 mg or 20 mg tadalafil showed significant improvement from baseline-to-end point on the Erectile Function domain of the International Index of Erectile Function (IIEF-EF) domain score in all clinical sub-populations analyzed, compared with patients receiving placebo (P < 0.001). The 10-mg and 20-mg tadalafil groups showed a mean success rate of 64.1% and 70.5% for sexual intercourse attempts (SEP3, successful intercourse), respectively, compared with 33.4% in the placebo group (P < 0.001), and 85.5% and 85.4% reported improved erections at end point GAQ, respectively, versus 43.5% in the placebo group (P < 0.001). Tadalafil was well tolerated across all groups studied. Headache and back pain were the most frequently reported adverse events. Overall, tadalafil was effective and well tolerated across a diverse clinical spectrum of Asian men with ED.
File Format	HTM / HTML
ISSN	1008682X
e-ISSN	17457262
DOI	10.1038/aja.2009.11
Journal	Asian Journal of Andrology
Issue Number	4
Volume Number	11
Language	English
Publisher	Wolters Kluwer - Medknow
Publisher Date	2009-07-01
Publisher Place	China
Access Restriction	Open
Subject Keyword	Discipline Urology Carbolines Therapeutic Use Erectile Dysfunction Drug Therapy Phosphodiesterase Inhibitors Ethnology Adverse Effects Double-blind Method Placebos Randomized Controlled Trials As Topic Tadalafil Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Urology

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Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis

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