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Year: 2014 Volume: 66 Issue: 1

Hypercholesterolemia and risk of incident psoriasis and psoriatic arthritis in US women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Shaowei Li, Wen-Qing Han, Jiali Sun, Qi Qureshi, Abrar A.
Spatial Coverage	United States
Description	Author Affiliation: Wu S ( Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.)
Abstract	OBJECTIVE: Psoriasis is a systemic inflammatory disorder associated with an increased risk of cardiovascular disease. Hypercholesterolemia is a major risk factor for cardiovascular disease, and patients with psoriasis or psoriatic arthritis (PsA) have been shown to have elevated cholesterol levels. However, it is not known whether hypercholesterolemia is associated with an increased risk of psoriasis or psoriasis with PsA. We undertook this study to determine whether a history of hypercholesterolemia is associated with the risk of developing incident psoriasis and psoriasis with PsA in a cohort of US women. METHODS: We included a total of 95,540 participants from the Nurses' Health Study II (1991-2005). Information on personal history of physician-diagnosed hypercholesterolemia and related medication use was collected during the followup period. Clinician-diagnosed psoriasis and psoriasis with PsA were ascertained and confirmed using supplementary questionnaires. Hazard ratios (HRs) were calculated with 95% confidence intervals (95% CIs). RESULTS: During 1,320,765 person-years of followup, we documented 646 participants with incident psoriasis, 165 of whom had concomitant PsA. Hypercholesterolemia was associated with elevated risks of incident psoriasis (HR 1.25 [95% CI 1.04-1.50]) and psoriasis with PsA (HR 1.58 [95% CI 1.13-2.23]) in multivariate-adjusted models. Participants with hypercholesterolemia lasting for ≥7 years were at a higher risk of developing psoriasis (HR 1.29 [95% CI 1.03-1.61]) (P for trend = 0.0002) and psoriasis with PsA (HR 1.68 [95% CI 1.12-2.52]) (P for trend = 0.002). These associations persisted among participants who never took cholesterol-lowering medications. There was no association between cholesterol-lowering drugs and risk of psoriasis or psoriasis with PsA. CONCLUSION: Our study provides evidence that hypercholesterolemia, a well-known cardiovascular risk factor, is also associated with an elevated risk of psoriasis and psoriasis with PsA.
File Format	HTM / HTML
ISSN	23265191
e-ISSN	23265205
DOI	10.1002/art.38227
Journal	Arthritis & Rheumatology
Issue Number	2
Volume Number	66
Language	English
Publisher	Wiley
Publisher Date	2014-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Rheumatology Arthritis, Psoriatic Epidemiology Hypercholesterolemia Complications Psoriasis Anticholesteremic Agents Therapeutic Use Cohort Studies Drug Therapy Retrospective Studies Risk Factors Questionnaires Time Factors Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Rheumatology

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