NDLI: Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor ß-responsive genes in osteoarthritis-related fibrosis.

Please wait, while we are loading the content...

Ultrasound assessment of synovial pathologic features in rheumatoid arthritis using comprehensive multiplane images of the second metacarpophalangeal joint: identification of the components that are reliable and influential on the global assessment of the whole joint.

Brief report: does medication use or disease activity during pregnancy in patients with rheumatoid arthritis affect bone density in their prepubertal offspring?

Reciprocal activation of CD4+ T cells and synovial fibroblasts by stromal cell-derived factor 1 promotes RANKL expression and osteoclastogenesis in rheumatoid arthritis.

MicroRNA-451 down-regulates neutrophil chemotaxis via p38 MAPK.

Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes.

Gene associated with retinoid-interferon-induced mortality 19 attenuates murine autoimmune arthritis by regulation of th17 and treg cells.

Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor Î³ is therapeutic in the collagen-induced arthritis experimental model.

In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis.

Involvement of peripheral and spinal tumor necrosis factor in spinal cord hyperexcitability during knee joint inflammation in rats.

A single functional group substitution in c5a breaks B cell and T cell tolerance and protects against experimental arthritis.

Impact of exercise type and dose on pain and disability in knee osteoarthritis: a systematic review and meta-regression analysis of randomized controlled trials.

In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.

Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor ß-responsive genes in osteoarthritis-related fibrosis.

Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.

Spinal inflammation in the absence of sacroiliac joint inflammation on magnetic resonance imaging in patients with active nonradiographic axial spondyloarthritis.

Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells.

Cooperation of factor VII-activating protease and serum DNase I in the release of nucleosomes from necrotic cells.

Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus.

Skin Progenitor Cells Contribute to Bleomycin-Induced Skin Fibrosis

Association of Interferon- and transforming growth factor ß-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis.

Brief report: lysyl oxidase is a potential biomarker of fibrosis in systemic sclerosis.

Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren's syndrome.

Predictors of clinical improvement in rituximab-treated refractory adult and juvenile dermatomyositis and adult polymyositis.

Distinct phenotype clusters in childhood inflammatory brain diseases: implications for diagnostic evaluation.

Predictors of new-onset widespread pain in older adults: results from a population-based prospective cohort study in the UK.

Year: 2014 Volume: 66 Issue: Supplementary 3

Year: 2014 Volume: 66 Issue: 2

Year: 2014 Volume: 66 Issue: 1

Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor ß-responsive genes in osteoarthritis-related fibrosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Remst, D. F. G. Blom, A. B. Vitters, E. L. Bank, R. A. Van Den Berg, W. B. Blaney Davidson, E. N. Van Der Kraan, P. M.
Description	Country affiliation: Netherlands Author Affiliation: Remst DF ( Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.)
Abstract	OBJECTIVE: Synovial fibrosis is a major contributor to joint stiffness in osteoarthritis (OA). Transforming growth factor ß (TGFß), which is elevated in OA, plays a key role in the onset and persistence of synovial fibrosis. However, blocking of TGFß in OA as a therapeutic intervention for fibrosis is not an option since TGFß is crucial for cartilage maintenance and repair. Therefore, we undertook the present study to seek targets downstream of TGFß for preventing OA-related fibrosis without interfering with joint homeostasis. METHODS: Experiments were performed to determine whether genes involved in extracellular matrix turnover were responsive to TGFß and were elevated in OA-related fibrosis. We analyzed gene expression in TGFß-stimulated human OA synovial fibroblasts and in the synovium of mice with TGFß-induced fibrosis, mice with experimental OA, and humans with end-stage OA. Gene expression was determined by microarray, low-density array, or quantitative polymerase chain reaction analysis. RESULTS: We observed an increase in expression of procollagen genes and genes encoding collagen crosslinking enzymes under all of the OA-related fibrotic conditions investigated. Comparison of gene expression in TGFß-stimulated human OA synovial fibroblasts, synovium from mice with experimental OA, and synovium from humans with end-stage OA revealed that the genes PLOD2, LOX, COL1A1, COL5A1, and TIMP1 were up-regulated in all of these conditions. Additionally, we confirmed that these genes were up-regulated by TGFß in vivo in mice with TGFß-induced synovial fibrosis. CONCLUSION: Most of the up-regulated genes identified in this study would be poor targets for therapy development, due to their crucial functions in the joint. However, the highly up-regulated gene PLOD2, responsible for the formation of collagen crosslinks that make collagen less susceptible to enzymatic degradation, is an attractive and promising target for interference in OA-related synovial fibrosis.
File Format	HTM / HTML
ISSN	23265191
Issue Number	3
Volume Number	66
e-ISSN	23265205
Journal	Arthritis & Rheumatology
Language	English
Publisher	Wiley
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Rheumatology Arthritis, Experimental Genetics Fibrosis Gene Expression Osteoarthritis Synovial Membrane Metabolism Transforming Growth Factor Beta Animals Pathology Cartilage Collagen Humans Mice Up-regulation Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Rheumatology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis

Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts

Deletion of the transforming growth factor ß receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness

Transforming growth factor-ß-independent role of connective tissue growth factor in the development of liver fibrosis.

Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis

Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls.

Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees

Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor ß-responsive genes in osteoarthritis-related fibrosis.

Similar Documents

Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis

Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts

Deletion of the transforming growth factor ß receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness

Transforming growth factor-ß-independent role of connective tissue growth factor in the development of liver fibrosis.

Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis

Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls.

Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees

Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor ß-responsive genes in osteoarthritis-related fibrosis.