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Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China.

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Year: 2014 Volume: 10 Issue: 2

Year: 2014 Volume: 10 Issue: 1

Clinical features of severe cases of hand, foot and mouth disease with EV71 virus infection in China.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Qi Zhang, Weidong Zhang, Ying Yan, Lei Wang, Shiwen Zhang, Jing Sun, Junling Chang, Zhaorui Wang, Zijun
Description	Author Affiliation: Wang Q ( National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.); Zhang W ( Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing, PR China ); Zhang Y ( Jiyuan City Center for Disease Control and Prevention, Jiyuan, PR China.); Yan L ( National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.); Wang S ( National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China.); Zhang J ( Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing, PR China.); Sun J ( Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing, PR China.); Chang Z ( Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing, PR China.); Wang Z ( Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing, PR China.)
Abstract	INTRODUCTION: Hand, foot and mouth disease (HFMD) caused by EV71 infection has become one of the major public health issues in China, which deeply affects children's health. The prevention and control of EV71 is a challenge currently because there is no safe and effective vaccine or antiviral medications available. MATERIAL AND METHODS: A case control study was conducted in a designated hospital to compare severe and mild cases of patients infected with the EV71 virus. Demographic information along with clinical features of HFMD was collected through a standardized questionnaire. Multi-factorial logistic regression was used to analyze independent associations between potential risk factors and severe HFMD. RESULTS: There were 120 cases (60 cases and 60 controls) collected. The male-to-female ratio was 1.3: 1 in the case group and 1.7: 1 in the control group. Multi-factorial logistic regression revealed that the main risk factors for severe cases were highest body temperature being ≥ 38.5°C (OR = 9.45, 95% CI: 2.07-43.11, p < 0.05), first visited a village level clinic (OR = 4.72, 95% CI: 1.15-19.45, p < 0.05), etc. CONCLUSIONS: Close surveillance combined with laboratory testing should be in place during the epidemic period of HFMD. Grass root level medical facilities and training of clinical and laboratory staff should be reinforced so that the diagnostic and treatment capacity can be improved.
File Format	HTM / HTML
ISSN	17341922
e-ISSN	18969151
DOI	10.5114/aoms.2014.43745
Journal	Archives of Medical Science
Issue Number	3
Volume Number	10
Language	English
Publisher	Termedia Pub. House
Publisher Date	2014-06-29
Publisher Place	Poland
Access Restriction	Open
Subject Keyword	Discipline Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine

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