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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schulman, N. F. Sahana, G. Iso-Touru, T. McKay, S. D. Schnabel, R. D. Lund, M. S. Taylor, J. F. Virta, J. Vilkki, J. H. |
| Description | Country affiliation: Finland Author Affiliation: Schulman NF ( MTT, Agrifood Research Finland, Biotechnology and Food Research, FIN-31600 Jokioinen, Finland. nina.schulman@mtt.fi) |
| Abstract | A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle. |
| File Format | HTM / HTML |
| ISSN | 02689146 |
| Issue Number | 3 |
| Volume Number | 42 |
| e-ISSN | 13652052 |
| Journal | Animal Genetics |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2011-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Genetics Discipline Zoology Cattle Genetics Chromosome Mapping Veterinary Fertility Genome-wide Association Study Animals Female Genetic Markers Genome Genotype Male Polymorphism, Single Nucleotide Quantitative Trait Loci Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Animal Science and Zoology |
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