NDLI: Sugammadex: A Scientific Review Including Safety and Efficacy, Update on Regulatory Issues, and Clinical Use in Europe.

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Sugammadex: A Scientific Review Including Safety and Efficacy, Update on Regulatory Issues, and Clinical Use in Europe.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jahr, Jonathan S. Miller, John E. Hiruma, Jessica Emaus, Katie You, Michelle Meistelman, Claude
Description	Country affiliation: France Author Affiliation: Jahr JS ( 1Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA)
Abstract	Muscle relaxants are used in the perioperative period to aid in endotracheal intubation, facilitate surgical exposure, and in the critical care setting for prolonged relaxation. Until now, the only mechanism to reverse their effect is acetylcholinesterase inhibitors that result in excess parasympathetic activity and require the second drug to prevent this side effect. Additionally, the onset and degree of neuromuscular antagonism are often unpredictable and unreliable. Sugammadex is the first of the cyclodextrins to be used as a therapeutic agent. It quickly, effectively, and safely reverses steroidal neuromuscular blockers by encapsulating the muscle relaxant and rendering it inactive. Sugammadex may be considered the ideal reversal agent and the first drug in its class, which will likely change the practice of anesthesia and clinical neuromuscular pharmacology.
File Format	HTM / HTML
ISSN	10752765
Issue Number	4
Volume Number	22
e-ISSN	15363686
Journal	American Journal of Therapeutics
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2015-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anesthesia Methods Delayed Emergence From Anesthesia Drug Therapy Muscle Relaxation Drug Effects Gamma-cyclodextrins Pharmacology Therapeutic Use Humans Treatment Outcome Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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Sugammadex: A Comprehensive Review of the Published Human Science, Including Renal Studies.

Reversing neuromuscular blockade: inhibitors of the acetylcholinesterase versus the encapsulating agents sugammadex and calabadion.

Sugammadex rescue following prolonged rocuronium neuromuscular blockade with 'recurarisation' in a patient with severe renal failure.

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Reversal of neuromuscular block with a selective relaxant-binding agent: sugammadex.

Sugammadex and residual neuromuscular block: what is acceptable normal practice?

Is one acceleromyographically measured train-of-four ratio sufficient after sugammadex to identify residual curarization in postoperative, awake patients?

Sugammadex: a cyclodextrin to reverse neuromuscular blockade in anaesthesia.

Drug-specific cyclodextrins with emphasis on sugammadex, the neuromuscular blocker rocuronium and perioperative anaphylaxis: implications for drug allergy.

Sugammadex: A Scientific Review Including Safety and Efficacy, Update on Regulatory Issues, and Clinical Use in Europe.

Similar Documents

Sugammadex: A Comprehensive Review of the Published Human Science, Including Renal Studies.

Reversing neuromuscular blockade: inhibitors of the acetylcholinesterase versus the encapsulating agents sugammadex and calabadion.

Sugammadex rescue following prolonged rocuronium neuromuscular blockade with 'recurarisation' in a patient with severe renal failure.

Sugammadex in anesthesia practice.

Reversal of neuromuscular block with a selective relaxant-binding agent: sugammadex.

Sugammadex and residual neuromuscular block: what is acceptable normal practice?

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Sugammadex: A Scientific Review Including Safety and Efficacy, Update on Regulatory Issues, and Clinical Use in Europe.