NDLI: Prevention of Preeclampsia with Aspirin in Multiple Gestations: A Systematic Review and Meta-analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bergeron, Tessa S. Roberge, Stéphanie Carpentier, Caroline Sibai, Baha McCaw-Binns, Affette Bujold, Emmanuel
Description	Country affiliation: Canada Author Affiliation: Bergeron TS ( Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec, Canada.); Roberge S ( Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Québec, Canada.); Carpentier C ( Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec, Canada.); Sibai B ( Department of Obstetrics and Gynecology, University of Texas Health Science Center, Houston, Texas.); McCaw-Binns A ( Department of Community Health and Psychiatry, University of the West Indies, Mona Kingston, Jamaica.); Bujold E ( Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec, Canada.)
Abstract	Objective The objective of this study was to estimate the effect of low-dose aspirin in multiple gestations to prevent preeclampsia and small for gestational age (SGA) neonates. Methods A systematic review and meta-analysis were performed through electronic database searches. Randomized controlled trials (RCTs) of women with multiple gestations assigned to receive aspirin or placebo or no treatment were included. Outcomes included preeclampsia (mild and severe) and SGA neonates. Relative risks (RR) with their 95% confidence intervals (CI) were calculated. Result Out of 6,853 citations, 6 RCTS, including 898 pregnancies, were included. We observed a significant reduction in the risk of preeclampsia (RR, 0.67; 95% CI, 0.48-0.94) and mild preeclampsia (RR, 0.44; 95% CI, 0.24-0.82) but not severe preeclampsia (RR, 1.02; 95% CI, 0.61-1.72) with low-dose aspirin. The risk of SGA was not changed (RR, 1.09; 95% CI, 0.80-1.47). The reduction of preeclampsia was not different between women randomized before (RR, 0.86; 95% CI, 0.41-1.81) or after 16 weeks' gestation (RR, 0.64; 95% CI, 0.43-0.96) (p = 0.50). Conclusion There is low level of evidence supporting the use of low-dose aspirin for the prevention of preeclampsia and SGA neonates in multiple gestations.
File Format	HTM / HTML
ISSN	07351631
e-ISSN	10988785
Journal	American Journal of Perinatology
Issue Number	6
Volume Number	33
Language	English
Publisher	Thieme
Publisher Date	2016-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Perinatology
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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