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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kapral, Malgorzata Strzalka, Barbara Kowalczyk, Malgorzata Jurzak, Magdalena Mazurek, Urszula Gierek, Tatiana Paluch, Jaroslaw Markowski, Jaroslaw Swiatkowska, Longina Weglarz, Ludmila |
| Description | Country affiliation: Poland Author Affiliation: Kapral M ( Department of Biochemistry, Medical University of Silesia, Sosnowiec, Poland. mkapral@slam.katowice.pl) |
| Abstract | PURPOSE: Cancerogenesis is a multistage process controlled by many cytokines, including growth factors. The aim of the study was the comparison of transcriptional activity of transforming growth factor beta (TGF-beta) genes in laryngeal squamous cell carcinomas and adjacent nonneoplastic tissues. MATERIALS AND METHODS: Tissues samples were obtained from 32 patients with laryngeal squamous cell carcinoma in histologic grades G1 to G3 who underwent surgical treatment at the ENT Clinics of Medical University of Silesia in Katowice, Poland. Quantification of gene expression was performed by real-time quantitative reverse transcriptase polymerase chain reaction technique. RESULTS: In tumor cells, expression of TGF-beta1 and TGF-beta2 isoforms (P < .001) was higher than in normal tissues. There was a positive correlation between the expression of TGF-beta1 and TGF-beta2 genes in tumors (R = 0.78, P = .0000) and adjacent normal tissues (R = 0.77, P = .0000). CONCLUSIONS: The results suggest that TGF-beta1 and TGF-beta2 messenger RNAs may be useful as molecular markers in distinguishing cancer from nonneoplastic tissues in laryngeal area. |
| File Format | HTM / HTML |
| ISSN | 01960709 |
| Issue Number | 4 |
| Volume Number | 29 |
| e-ISSN | 1532818X |
| Journal | American Journal of Otolaryngology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Otolaryngology Carcinoma, Squamous Cell Genetics Laryngeal Neoplasms Rna, Messenger Analysis Transforming Growth Factor Beta2 Transforming Growth Factor Beta3 Tumor Markers, Biological Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Reverse Transcriptase Polymerase Chain Reaction Transcription, Genetic Transforming Growth Factor Beta1 Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology |
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