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TSPO 18 kDa (PBR) Targeted Photosensitizers for Cancer Imaging (PET) and PDT.

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TSPO 18 kDa (PBR) Targeted Photosensitizers for Cancer Imaging (PET) and PDT.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Yihui Sajjad, Munawwar Wang, Yanfang Batt, Carrie Nabi, Hani A. Pandey, Ravindra K.
Description	Country affiliation: United States Author Affiliation: Chen Y ( PDT Center, Roswell Park Cancer Institute, Buffalo, New York 14263, United States ); Sajjad M ( Department of Nuclear Medicine, State University of New York, Buffalo, New York 14214, United States.); Wang Y ( PDT Center, Roswell Park Cancer Institute, Buffalo, New York 14263, United States.); Batt C ( PDT Center, Roswell Park Cancer Institute, Buffalo, New York 14263, United States.); Nabi HA ( Department of Nuclear Medicine, State University of New York, Buffalo, New York 14214, United States.); Pandey RK ( PDT Center, Roswell Park Cancer Institute, Buffalo, New York 14263, United States.)
Abstract	Translocator protein (TSPO) 18 kDa overexpression has been observed in a large variety of human cancers, especially breast cancers. PK 11195, an isoquinoline analogue, is one of the ligands of highest TSPO binding affinity. Due to the long biological half life of our photosensitizers, there is a need to label them with a long lived radioisotope, for example I-124. Our objectives are to find translocator protein targeted photosensitizers for both tumor imaging (PET) and photodynamic therapy (PDT). I-PK 11195 is conjugated with the tumor avid photosensitizer HPPH. We find that those two tumor avid components complement each other and make the conjugate molecule even more tumor avid; compared to the photosensitizer itself, the conjugate is found to show improved PDT efficacy. It is concluded that I-PK 11195 can be a good vehicle to deliver radionuclide and photosensitizer to TSPO overexpressed tumor regions. Such conjugates could be useful for both tumor imaging (PET) and PDT.
File Format	HTM / HTML
e-ISSN	19485875
DOI	10.1021/ml100211g
Journal	ACS Medicinal Chemistry Letters
Issue Number	2
Volume Number	2
Language	English
Publisher	American Chemical Society
Publisher Date	2011-02-10
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Chemistry
Content Type	Text
Resource Type	Article

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