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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Safarinejad, Mohammad Reza |
| Description | Country affiliation: Iran Author Affiliation: Safarinejad MR ( Urology and Nephrology Research Center, Shahid Beheshti University (MS), Teheran, Iran. safarinejad@urologist.md) |
| Abstract | PURPOSE: We determined the safety and efficacy of sorafenib in patients with castrate resistant prostate cancer (CRPC). METHODS: Sixty-four chemotherapy and radiotherapy naïve patients with CRPC received 400 mg sorafenib orally twice daily in 6-week cycles. All patients had bone metastasis, while 16 had lymph node-, 9 had liver-, and 10 had lung metastases. Treatment was continued until disease progression or excessive toxicity. RESULTS: All patients were assessable for response. A median of 6.4 consecutive cycles was administered per patient. Median overall survival for all patients was 14.6 months (confidence interval [CI], 8.2-22.2). No complete response (CR) occurred. Of the 35 patients with measurable extraosseous disease, 7 (20%) had a partial response. Overall, 13 patients (20.3%; 95% CI, 4%-32%) achieved a 50% or greater reduction (partial response [PR]) in prostate-specific antigen (PSA) level after two cycles. The median response duration was 2.5 months (95% CI, 1.4 to 4.8), and the median time to progression was 5.9 months (95% CI 3.6 to 7.6). There was no treatment-related death. Toxicities were well tolerated. CONCLUSIONS: Sorafenib demonstrated some antitumor activity. Further studies are necessary to determine a subgroup of patients who would likely respond better to sorafenib. |
| File Format | HTM / HTML |
| ISSN | 10781439 |
| Issue Number | 1 |
| Volume Number | 28 |
| e-ISSN | 18732496 |
| Journal | Urologic Oncology: Seminars and Original Investigations |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Urology Discipline Oncology Adenocarcinoma Drug Therapy Antineoplastic Agents Therapeutic Use Benzenesulfonates Prostatic Neoplasms Pyridines Surgery Aged Aged, 80 And Over Adverse Effects Humans Male Middle Aged Niacinamide Analogs & Derivatives Orchiectomy Phenylurea Compounds Prospective Studies Treatment Failure Young Adult Clinical Trial, Phase Ii Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Urology Oncology |
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