NDLI: Commentary on 'Smoking negatively affects renal cell carcinoma overall and cancer-specific survival.' Kroeger N, Klatte T, Birkhäuser FD, Rampersaud EN, Seligson DB, Zomorodian N, Kabbinavar FF, Belldegrun AS, Pantuck AJ, Institute of Urologic Oncology, David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, CA: Cancer 2012;118(7):1795-802 (Epub 2011 Aug 25).

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Robot-assisted laparoscopic partial nephrectomy for tumors greater than 4 cm and high nephrometry score: feasibility, renal functional, and oncological outcomes with minimum 1 year follow-up.

Presence of high grade tertiary Gleason pattern upgrades the Gleason sum score and is inversely associated with biochemical recurrence-free survival.

Is there a role for partial nephrectomy in patients with metastatic renal cell carcinoma?

Pathologic implications of prostatic anterior fat pad.

Apoptosis gene polymorphisms and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy.

A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer.

Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel.

Prognostic prediction in patients with metastatic renal cell carcinoma treated with sorafenib based on expression levels of potential molecular markers in radical nephrectomy specimens.

MiR-133a induces apoptosis through direct regulation of GSTP1 in bladder cancer cell lines.

An alternative treatment regimen of advanced seminoma with carboplatin, etoposide, and bleomycin instead of cisplatin-based therapy.

Outcomes of Korean patients with clinically localized urachal or non-urachal adenocarcinoma of the bladder.

Postoperative intensity-modulated radiotherapy with simultaneous integrated boost in prostate cancer: a dose-escalation trial.

Evaluation of combined oncologic and functional outcomes after robotic-assisted laparoscopic extraperitoneal radical prostatectomy: trifecta rate of achieving continence, potency and cancer control.

Complications of laparoscopic partial nephrectomy.

Elimination of preoperative mechanical bowel preparation in patients undergoing cystectomy and urinary diversion.

Attenuation of androgenic regulation by brefeldin A in androgen-responsive prostate cancer cells.

Commentary on 'Long-term survival following partial vs. radical nephrectomy among older patients with early-stage kidney cancer.' Tan HJ, Norton, EC, Ye Z, Hafez KS, Gore JL, Miller DC, Dow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, MI: JAMA 2012;307(15):1629-35.

Commentary on 'Smoking negatively affects renal cell carcinoma overall and cancer-specific survival.' Kroeger N, Klatte T, Birkhäuser FD, Rampersaud EN, Seligson DB, Zomorodian N, Kabbinavar FF, Belldegrun AS, Pantuck AJ, Institute of Urologic Oncology, David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, CA: Cancer 2012;118(7):1795-802 (Epub 2011 Aug 25).

Commentary on 'Conditional survival of patients with metastatic renal cell carcinoma treated with VEGF-targeted therapy: A population-based study.' Harshman LC, Xie W, Bjarnason GA, Knox JJ, MacKenzie M, Wood L, Srinivas S, Vaishampayan UN, Tan MH, Rha SY, Donskov F, Agarwal N, Kollmannsberger C, North S, Rini BI, Heng DY, Choueiri TK, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA: Lancet Oncol 2012;13(9):927-35 (Epub 2012 Aug 8).

Commentary on 'Detailed analysis of morbidity following nephrectomy for renal cell carcinoma in octogenarians.' Berger J, Fardoun T, Brassart E, Capon G, Bigot P, Bernhard JC, Rigaud J, Patard JJ, Descazeaud A, Department of Urology, Dupuytren University Hospital, Limoges, France: J Urol 2012;188(3):736-40 (Epub 2012 Jul 19).

Commentary on 'Off-clamp vs. complete hilar control laparoscopic partial nephrectomy: Comparison by clinical stage.' Rais-Bahrami S, George AK, Herati AS, Srinivasan AK, Richstone L, Kavoussi LR, Arthur Smith Institute for Urology, North Shore-Long Island Jewish Health System, New Hyde Park, NY: BJU Int 2012;109(9):1376-81 (Epub 2011 Oct 12).

Commentary on 'Benzodiazepine use possibly increases cancer risk: A population-based retrospective cohort study in Taiwan.' Kao CH, Sun LM, Su KP, Chang SN, Sung FC, Muo CH, Liang JA, Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.: J Clin Psychiatry 2012;73(4):e555-e60.

Commentary on 'Laparoendoscopic single-site (LESS) partial nephrectomy short-term outcomes.' Rais-Bahrami S, George AK, Montag S, Okhunov Z, Richstone L, The Arthur Smith Institute for Urology, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY: BJU Int 2012 (Epub ahead of print).

Commentary on 'Radiofrequency ablation of incidental benign small renal mass: outcomes and follow-up protocol.' Tan YK, Best SL, Olweny E, Park S, Trimmer C, Cadeddu JA, Department of Urology, University of Texas Southwestern Medical School, Dallas, Texas, TX.

Commentary on 'Predicting the histology of small renal masses using preoperative dynamic contrast-enhanced magnetic resonance imaging.' Kim JH, Bae JH, Lee KW, Kim ME, Park SJ, Park JY, Department of Urology, Soonchunhyang University Hospital, Seoul, Korea.

Year: 2012 Volume: 30

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Year: 2005 Volume: 23

Commentary on 'Smoking negatively affects renal cell carcinoma overall and cancer-specific survival.' Kroeger N, Klatte T, Birkhäuser FD, Rampersaud EN, Seligson DB, Zomorodian N, Kabbinavar FF, Belldegrun AS, Pantuck AJ, Institute of Urologic Oncology, David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, CA: Cancer 2012;118(7):1795-802 (Epub 2011 Aug 25).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Boorjian, Stephen
Abstract	Tobacco use is a leading cause of premature death, yet few studies have investigated the effect of tobacco exposure on the outcome of patients with renal cell carcinoma (RCC). The authors of this report retrospectively studied the affect of smoking on clinicopathologic factors, survival outcomes, and p53 expression status in a large cohort of patients with RCC. Eight hundred and two patients (457 nonsmokers and 345 smokers) who had up to 232 months of follow-up were compared for differences in their clinicopathologic features and survival outcomes. Immunohistochemical differences in p53 expression were correlated with smoking status. Smokers presented more commonly with pulmonary comorbidities (P <0.0001) and cardiac comorbidities (P = 0.014) and with a worse performance status (P = 0.031) than nonsmokers. Smoking was associated significantly with tumor multifocality (P = 0.022), higher pathologic tumor classification (P = 0.037), an increased risk of bulky lymph node metastases (P = 0.031), and the presence of distant metastases (P <0.0001), especially lung metastases (P <0.0001). Both overall survival (62.37 months vs. 43.64 months; P = 0.001) and cancer-specific survival (CSS) (87.43 months vs. 56.57 months; P = 0.005) were significantly worse in patients who smoked. The number of pack-years was retained as an independent predictor of CSS and overall survival in patients with nonmetastatic disease. Mean expression levels of p53 were significantly higher in current smokers compared with former smokers and nonsmokers (P = 0.012). In patients with RCC, a history of smoking was associated with worse pathologic features and survival outcomes, and with an increased risk of having mutated p53. Further investigation of the genetic and molecular mechanisms associated with decreased CSS in patients with RCC who have a history of smoking is indicated.
File Format	HTM / HTML
ISSN	10781439
Issue Number	1
Journal	Urologic Oncology: Seminars and Original Investigations
Volume Number	31
e-ISSN	18732496
Language	English
Publisher	Elsevier
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Urology Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Urology Oncology

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Los angeles, cal.: nuisances. (ord. 30619, aug. 13, 1914)

Los angeles, cal.: stables. washracks. (ord. 30619, aug. 13, 1914)

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Los angeles, cal.: manure. care and disposal. (ord. 30619, aug. 13, 1914)

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Los angeles, cal.: births and deaths. registration of. (ord. 30619, aug. 13, 1914)

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