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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cetnar, Jeremy Wilding, George McNeel, Douglas LoConte, Noelle K. McFarland, Thomas A. Eickhoff, Jens Liu, Glenn |
| Description | Country affiliation: United States Author Affiliation: Cetnar J ( University of Wisconsin Carbone Cancer Center, Wisconsin Institutes for Medical Research, Madison, WI 53705, USA. jpcetnar@medicine.wisc.edu) |
| Abstract | BACKGROUND: Satraplatin is an oral platinum with potential advantages over other platinum agents. This study investigated the combination of satraplatin and docetaxel in a phase 1 study of patients with advanced solid tumor malignancies followed by a phase 1b study in men with chemotherapy naïve metastatic castrate-resistant prostate cancer (CRPC). METHODS: In this single institution phase 1/1b study, patients received docetaxel on day 1 and satraplatin on days 1-5 of a 21-day cycle ± granulocyte colony stimulating factor (GCSF). For phase 1b, prednisone 10 mg daily was added. RESULTS: Twenty-nine patients received treatment. Based on 3 dose limiting toxicities (DLT) (grade 4 neutropenia) in 13 patients at dose levels 1 and -1 (docetaxel 60 mg/m(2) plus satraplatin 40 mg/m(2) and docetaxel 60 mg/m(2) plus satraplatin 50 mg/m(2)) GCSF was administered with subsequent cohorts. A dose level of docetaxel 60 mg/m(2) plus satraplatin 50 mg/m(2) with GCSF was the starting dose level for phase 1b. At the highest dose in the phase 1b (docetaxel 75 mg/m(2) plus satraplatin 50 mg/m(2)) there were no DLTs. CONCLUSION: The combination of satraplatin and docetaxel is feasible in solid tumor malignancies. In advanced malignancies, the recommended phase 2 dose is docetaxel 60 mg/m(2) IV day 1 with satraplatin 40 mg/m(2)/d PO days 1-5, without G-CSF, and Docetaxel 70 mg/m(2) IV day 1 with Satraplatin 50 mg/m(2)/day PO days 1-5, with G-CSF support, repeated in 3-week cycles. For patients with CRPC the recommended phase 2 dose is docetaxel 75 mg/m(2) IV day 1 with satraplatin 50 mg/m(2)/d PO days 1--5, with G-CSF and prednisone 10 mg daily, repeated in 3-week cycles. |
| File Format | HTM / HTML |
| ISSN | 10781439 |
| e-ISSN | 18732496 |
| DOI | 10.1016/j.urolonc.2011.02.007 |
| Journal | Urologic Oncology: Seminars and Original Investigations |
| Issue Number | 4 |
| Volume Number | 31 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Urology Discipline Oncology Adenocarcinoma Drug Therapy Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Castration Neoplasms Prostatic Neoplasms Pathology Maximum Tolerated Dose Neoplasm Metastasis Organoplatinum Compounds Administration & Dosage Prognosis Taxoids Clinical Trial, Phase I Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Urology Oncology |
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