NDLI: Efficacy of doxazosin in the treatment of acute urinary retention due to benign prostate hyperplasia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Prieto, Luis Romero, Jesús López, Cristóbal Ortiz, Manuel Pacheco, Juan Jose
Description	Country affiliation: Spain Author Affiliation: Prieto L ( Urodynamics Unit, Department of Urology, San Juan University Hospital, San Juan/Alicante, Spain. prieto_lui@gva.es)
Abstract	OBJECTIVE: To evaluate the efficacy of modified-release doxazosin 4 mg in the treatment of patients with acute urinary retention (AUR) due to benign prostate gland hyperplasia (BPH). An evaluation is made of the number of patients recovering spontaneous micturition after catheter removal, micturition quality, and the number of patients suffering new AUR episodes or who require surgery in the 2 years following the first episode. PATIENTS AND METHODS: A randomized, controlled study in males with AUR secondary to BPH. Two groups are formed, administering modified-release doxazosin 4 mg to patients born in even-numbered years, once a day in the morning. Those born in odd-numbered years receive no medication. The catheter is withdrawn 1 month later. Flowmetry is performed, with determination of ultrasonographic postmicturition retention at withdrawal, and after 6, 12 and 24 months. RESULTS: Of the 65 patients included, 47 proved evaluable, and 46 complied with treatment (with exclusion of 1 case due to hypotension). Of the 22 patients treated with doxazosin, 15 (68.86%) presented AUR after 2 years, while 7 (31.2%) showed spontaneous micturition. Of the 24 patients treated with bladder catheterization in the absence of medication, 16 (66.6%) presented AUR after the same period of time, while 8 (33.3%) showed spontaneous micturition. There were no statistically significant differences between the treated and untreated subjects in terms of drug efficacy. Residual flow parameters are described in the population with spontaneous micturition in each stage of the study. CONCLUSION: In our series, treatment with the alpha-blocker doxazosin (4 mg, modified-release formulation), added to bladder catheterization, showed no increased efficacy in AUR treatment versus catheterization alone. Two years after the urinary retention episode, 31.2% of the patients treated with modified-release doxazosin 4 mg, and 33.3% of those with a bladder catheter only were seen to maintain spontaneous micturition.
File Format	HTM / HTML
ISSN	00421138
Issue Number	1
Volume Number	81
e-ISSN	14230399
Journal	Urologia Internationalis
Language	English
Publisher	Karger
Publisher Date	2008-01-01
Publisher Place	Switzerland
Access Restriction	Subscribed
Subject Keyword	Discipline Urology Doxazosin Pharmacology Prostatic Hyperplasia Drug Therapy Urinary Retention Etiology Acute Disease Adrenergic Alpha-antagonists Aged Aged, 80 And Over Delayed-action Preparations Humans Male Middle Aged Complications Treatment Outcome Urinary Bladder Pathology Urinary Catheterization Urination Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Urology

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