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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jobim, M. Jobim, L. F. J. Salim, P. H. Cestari, T. F. Toresan, R. Gil, B. C. Jobim, M. R. Wilson, T. J. Kruger, M. Schlottfeldt, J. Schwartsmann, G. |
| Spatial Coverage | Brazil |
| Description | Country affiliation: Brazil Author Affiliation: Jobim M ( Department of Immunology, Hospital de Clínicas, Porto Alegre, Brazil. mjobim@hcpa.ufrgs.br) |
| Abstract | Psoriasis is a chronic inflammatory skin disease whose pathogenesis and genetic background remain unclear. Considering that previous studies have suggested an association of psoriasis vulgaris (PV) and killer cell immunoglobulin-like receptors (KIRs), we typed 15 KIR genes and human leukocyte antigen (HLA)-Cw in 79 Brazilian Caucasoid patients with PV and 110 healthy controls by polymerase chain reaction (PCR) using sequence-specific oligonucleotides and sequence-specific primers. We did not observe a relevant increase in the frequency of the activating KIR2DS1 gene in the PV group [KIR2DS1, 46 of 79 cases (58.2%) vs 40 of 110 controls (36.4%)]. However, an association of KIR2DS1 with Cw*0602+ in 26.5% of PV patients was observed, while it was present in only 5.4% of controls. These results suggest that activating KIR2DS1 gene may not confer susceptibility to PV, and an association of KIR2DS1 gene with the HLA-Cw*0602+ was observed in these patients. |
| File Format | HTM / HTML |
| ISSN | 20592302 |
| Issue Number | 4 |
| Volume Number | 72 |
| e-ISSN | 20592310 |
| Journal | Tissue Antigens |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Genetics Discipline Immunology Hla-c Antigens Genetics Psoriasis Receptors, Kir Alleles Brazil Epidemiology Gene Frequency Genetic Predisposition To Disease Humans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Immunology and Allergy Immunology |
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