NDLI: Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.

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Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.

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Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Douroudis, K. Prans, E. Haller, K. Nemvalts, V. Rajasalu, T. Tillmann, V. Kisand, K. Uibo, R.
Spatial Coverage	Estonia
Description	Country affiliation: Estonia Author Affiliation: Douroudis K ( Department of Immunology, IGMP, Centre of Molecular and Clinical Medicine, University of Tartu, Tartu, Estonia.)
Abstract	Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is considered an important regulator of T-cell activation. Polymorphisms within the PTPN22 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes (T2D), the PTPN22 C1858T single nucleotide polymorphism (SNP) was studied in the population of Estonian origin, including 170 T1D patients, 244 T2D patients and 230 controls. Using two methods for PTPN22 C1858T detection in parallel, we found that not only T1D but also T2D is associated with the PTPN22 1858T allele. The role of PTPN22 gene in the pathogenesis of T2D is yet unclear and needs further investigation.
File Format	HTM / HTML
ISSN	20592302
Issue Number	5
Volume Number	72
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-11-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Diabetes Mellitus, Type 1 Genetics Diabetes Mellitus, Type 2 Protein Tyrosine Phosphatase, Non-receptor Type 22 Adult Aged Alleles Case-control Studies Epidemiology Estonia Female Genetic Predisposition To Disease Genotype Humans Male Middle Aged Polymorphism, Single Nucleotide Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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Association between the 1858T allele of the protein tyrosine phosphatase nonreceptor type 22 and type 1 diabetes in a Brazilian population.

Association of PTPN22+1858C/T polymorphism with Type 1 diabetes in the North Indian population.

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Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis.

PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients.

The role of polymorphic protein tyrosine phosphatase non-receptor type 22 in leprosy.

Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.

Association of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and Kruppel-like factor 12 (KLF12) rs1324913 single nucleotide polymorphisms with rheumatoid arthritis in a Latvian population.

Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population.

Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.

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Association between the 1858T allele of the protein tyrosine phosphatase nonreceptor type 22 and type 1 diabetes in a Brazilian population.

Association of PTPN22+1858C/T polymorphism with Type 1 diabetes in the North Indian population.

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Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.