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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Song, M. J. Lee, C. W. Kim, J. H. Lee, S. J. Kim, C. J. Hur, S. Y. Park, T. C. Kim, T. G. Park, J. S. |
| Spatial Coverage | Republic of Korea |
| Description | Country affiliation: South Korea Author Affiliation: Song MJ ( Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea.) |
| Abstract | This study investigated whether killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles, receptors and ligands of natural killer cells are associated with the development of human papillomavirus (HPV)-related cervical disease in Korean women. Blood samples from 132 women with HPV-related cervical disease and 159 women without HPV infection were collected for genotyping of KIR genes and HLA-C alleles. Although no relationship was found between KIR genes and HPV-related cervical disease, a significant relationship was found between HLA-C alleles as ligands of KIR and HPV-related cervical disease. Women with HPV-related cervical disease were found to be significantly more likely to carry HLA-C*0303, particularly those with HPV 16 or 18 infection, and less likely to carry HLA-C*01 compared to women without HPV infection. HLA-C*0303 was found to confer susceptibility to HPV-related cervical disease, whereas HLA-C*01 was found to confer a protective effect against HPV-related cervical disease. |
| File Format | HTM / HTML |
| ISSN | 20592302 |
| Issue Number | 3 |
| Volume Number | 81 |
| e-ISSN | 20592310 |
| Journal | Tissue Antigens |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Genetics Discipline Immunology Alleles Asian Continental Ancestry Group Genetics Genetic Predisposition To Disease Hla-c Antigens Papillomavirus Infections Receptors, Kir Uterine Cervical Neoplasms Adult Aged Female Genetic Association Studies Immunology Humans Middle Aged Republic Of Korea Risk Factors Virology Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Immunology and Allergy Immunology |
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