NDLI: Polymorphism in NFKBIA gene is associated with recurrent acute rejections in liver transplant recipients.

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Polymorphism in NFKBIA gene is associated with recurrent acute rejections in liver transplant recipients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kramer, K. Thye, T. Treszl, A. Peine, S. Koch, M. Sterneck, M. Nashan, B. Thude, H.
Description	Country affiliation: Germany Author Affiliation: Kramer K ( Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.)
Abstract	The nuclear factor of kappa light polypeptide gene enhancer B-cells inhibitor-alpha (NFKBIA) gene encodes a member of the nuclear factor-kappa-B inhibitor family. Polymorphisms in this gene might be associated with a susceptibility to acute rejection episodes following liver transplantation, as they may cause an increased activation level of the proinflammatory transcription factor nuclear factor of kappa light polypeptide gene enhancer in B-cells (NFκB). The aim of this study was to evaluate whether the NFKBIA polymorphisms -297 C/T (rs2233409), -826 C/T (rs2233406) and 126 G/A (rs696) affect the incidence of acute liver graft rejection. A total of 199 liver transplant recipients was analyzed, 100 without (NAR) and 99 with early acute rejection (AR). Thirty-two individuals with multiple acute rejections (MAR) were analyzed as a subgroup of AR. Polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA) and allele-specific hybridization with fluorescence resonance energy transfer (FRET) were used for genotyping. We identified the genotype NFKBIA 126 AA (P = 0.002) as well as the haplotype NFKBIA-126A-297T-826T (P = 0.002) as a potential risk factor for the occurrence of recurrent acute rejections. Furthermore, we assessed an association between the 126 A allele and susceptibility to recurrent acute rejections (P = 0.027). Our data suggest that the NFKBIA 126 G/A polymorphism might be potentially helpful to identify liver transplant recipients with an increased susceptibility to develop recurrent acute rejections.
File Format	HTM / HTML
ISSN	20592302
Issue Number	4
Volume Number	84
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Alleles Genetic Predisposition To Disease Graft Rejection Genetics I-kappa B Proteins Liver Transplantation Polymorphism, Genetic Acute Disease Adult Female Genotyping Techniques Humans Male Middle Aged Polymerase Chain Reaction Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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Polymorphism in NFKBIA gene is associated with recurrent acute rejections in liver transplant recipients.